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Preclinical Development: Overview

Preclinical Development: Overview

Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...

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Related Experiment Video

Updated: Jul 19, 2025

Subtype-selective Electroporation of Cortical Interneurons

Subtype-selective Electroporation of Cortical Interneurons

Published on: August 18, 2014

The NIMH Research Portfolio: An Update.

E Fuller Torrey^1,2,3, Wendy W Simmons¹, Lisa Dailey²

¹Stanley Medical Research Institute, Rockville, Maryland.

The Primary Care Companion for CNS Disorders

|August 7, 2023

Summary

This summary is machine-generated.

The National Institute of Mental Health (NIMH) increased its budget but decreased funding for clinical trials for severe mental illnesses. This shift prioritizes basic research over developing treatments for conditions like schizophrenia and bipolar disorder.

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Area of Science:

Mental Health Research Funding
Psychiatric Disorder Research

Background:

The National Institute of Mental Health (NIMH) is a key funder of mental health research.
Assessing funding allocation is crucial for understanding research progress.

Purpose of the Study:

To evaluate NIMH's funding priorities since 2016.
To determine if basic research is prioritized over clinical research.

Main Methods:

Analysis of ClinicalTrials.gov and NIH Research, Condition, and Disease Categorization (RCDC) databases.
Assessment of NIMH funding for six psychiatric disorders (schizophrenia, bipolar disorder, depression, anxiety, eating disorders, autism) from 2016 onwards.

Main Results:

NIMH funding for schizophrenia and bipolar disorder research decreased by 22% and 20% respectively (2016-2021).
Clinical trial funding for schizophrenia and bipolar disorder was minimal (1 trial each, 2017-2022).
NIMH's budget increased by 40% during the same period, with a continued emphasis on basic research.

Conclusions:

NIMH's funding priorities favor basic research over clinical trials.
This trend may hinder the development of treatments for severe psychiatric disorders.