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Relationship Between Blood Monocyte-HDL Ratio and Carotid Intima Media Thickness in with Postmenopausal Women

Ender Erden1, Ayla Cagliyan Turk1, Nurdan Fidan2

  • 1Faculty of Medicine, Department of Physical Medicine and Rehabilitation, Hitit University, Corum 19200, Turkey.

Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry
|August 7, 2023
PubMed

Insights

The monocyte-to-HDL ratio (MHR) did not differ significantly in postmenopausal women with osteoporosis. However, MHR and monocyte counts correlated with bone density, while carotid intima media thickness indicated increased fracture risk.

Area of Science:

  • Endocrinology
  • Gerontology
  • Rheumatology

Background:

  • The monocyte-to-high-density lipoprotein ratio (MHR) and carotid intima media thickness (CIMT) are potential markers for inflammation and oxidative stress.
  • Osteoporosis in postmenopausal women is a significant health concern, often associated with increased fracture risk and reduced quality of life (QoL).

Purpose of the Study:

  • To investigate the role of MHR in the etiopathogenesis of postmenopausal osteoporosis.
  • To determine the association between MHR, CIMT, fracture risk, and QoL in postmenopausal women without comorbidities.

Main Methods:

  • A prospective study involving 180 postmenopausal women categorized into osteoporosis, osteopenia, and control groups.
  • Evaluated monocyte, HDL, and MHR levels; bone mineral density (DXA); fracture risk (Turkish FRAX); QoL (QUALEFFO-41); and CIMT (ultrasonography).

Main Results:

  • MHR, monocyte, and HDL levels were similar across all groups.
  • CIMT was significantly higher in the osteoporosis group compared to the control group.
  • Positive correlations were observed between MHR and QUALEFFO-41 total score, and between monocytes and L1-4 T-score. CIMT showed a negative correlation with L1-4 T-score and was associated with increased fracture risk.

Conclusions:

  • MHR did not differ between osteoporosis, osteopenia, and control groups in postmenopausal women without comorbidities.
  • Monocyte count and MHR correlate with bone mineral density (femoral neck and L1-4 T-scores).
  • CIMT is associated with lower bone density and higher fracture risk, independent of MHR.
Abstract

Keywords:
Fracture riskMonocyte-to-HDL cholesterol ratioOsteoporosisQuality of life

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