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Progress on the pathological tissue microenvironment barrier-modulated nanomedicine.

Han Han1, Lei Xing2, Bi-Te Chen1

  • 1State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 211198, China.

Advanced Drug Delivery Reviews
|August 7, 2023
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Summary

Tissue barriers hinder drug delivery, but nanomedicine can overcome these challenges. This review explores pathological barriers and barrier-modulated nanomedicine for enhanced therapeutic efficacy.

Keywords:
Biological barriersCytoprotective barriersDrug delivery systemPhysiological barriers repairTissue physical barriers

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Pharmacology

Background:

  • The tissue microenvironment presents significant physical and biological barriers to effective drug delivery and distribution.
  • Existing research primarily addresses normal physiological barriers, neglecting the critical role of pathological microenvironments in drug hindrance.
  • Repairing damaged physiological barriers is crucial for disease treatment and maintaining homeostasis.

Purpose of the Study:

  • To provide a comprehensive overview of pathological barriers affecting drug delivery.
  • To review recent advancements in barrier-modulated nanomedicine strategies.
  • To highlight the importance of both modulating pathological barriers and repairing physiological barriers.

Main Methods:

  • Literature review of recent advances in nanomedicine and drug delivery.
  • Analysis of challenges posed by pathological tissue microenvironments.
  • Discussion of nanomedicine designs for overcoming biological and physical barriers.

Main Results:

  • Pathological tissue microenvironments present multifaceted barriers to therapeutic agents.
  • Nanomedicine offers promising strategies for navigating and modulating these barriers.
  • Addressing both pathological and physiological barriers is essential for successful drug delivery.

Conclusions:

  • Modulating pathological barriers and repairing physiological barriers are key to improving drug efficacy.
  • Future nanomedicine design should focus on overcoming diverse tissue microenvironment challenges.
  • This review provides a framework for developing next-generation nanotherapeutics.