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Association between serum complement 1q and the associated factors of acute ischemic stroke in patients with type 2
Zhen-Ping Hu1, Fang Wu2, Yuan-Hong Du2
1Department of Endocrinology, The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, Enshi, China.
Insights
Serum complement 1q (C1q) levels are elevated in patients with type 2 diabetes and acute ischemic stroke. C1q is an independent risk factor for stroke in this population.
Area of Science:
- Biochemistry
- Clinical Medicine
- Cardiovascular Research
Background:
- Type 2 diabetes (T2DM) is a significant risk factor for cardiovascular diseases, including acute ischemic stroke.
- Understanding the underlying mechanisms and identifying reliable biomarkers for stroke risk in T2DM patients is crucial.
Purpose of the Study:
- To investigate the association between serum complement 1q (C1q) levels and acute ischemic stroke in patients with type 2 diabetes.
- To determine if C1q is an independent risk factor for acute ischemic stroke in this patient group.
Main Methods:
- Collected baseline clinical data, blood lipids, blood sugar, inflammatory cytokines, and C1q levels from three groups.
- Utilized receiver operating characteristic (ROC) curve analysis, Pearson's correlation, and logistic regression models.
- Performed stratified analysis to assess relationships within specific strata of associated factors.
Main Results:
- Serum C1q levels were significantly higher in patients with type 2 diabetes and acute ischemic stroke (DAIS group) compared to those with T2DM alone.
- C1q demonstrated good diagnostic performance for acute ischemic stroke (AUC=0.830).
- C1q positively correlated with low-density lipoprotein cholesterol (LDL-C), fasting blood glucose (PBG), 2-h postprandial blood glucose (2h PG), and high-sensitive C-reactive protein (hs-CRP).
- Logistic analysis identified C1q as an independent risk factor for acute ischemic stroke in T2DM patients.
- A one-SD increase in C1q was associated with a 1.5-fold increased stroke risk in patients with hs-CRP ≥1.78 mg/L.
Conclusions:
- Elevated serum C1q levels are significantly associated with acute ischemic stroke in patients with type 2 diabetes.
- Serum C1q is an independent risk factor contributing to the occurrence of acute ischemic stroke in this population.
Objective:
The aim of this study was to examine the association between serum complement 1q (C1q) and the associated factors of acute ischemic stroke in patients with type 2 diabetes (T2DM).
Methods:
The baseline clinical variables of the participants were collected, and the levels of blood lipids, blood sugar, inflammatory cytokines, and C1q in the three groups were then compared. The variables which affected the associated factors of acute ischemic stroke in T2DM cases were determined.
Results:
The levels of C1q in the DAIS group were increased significantly compared with those in the T2DM group. Receiver operating characteristic curve analyses showed that the AUC for C1q and the combined diagnosis of acute ischemic stroke were 0.830 (95%CI 0.747-0.914), with a sensitivity of 0.854 and specificity of 0.780. The results of Pearson's correlation analyses demonstrated that C1q was associated positively with low-density lipoprotein cholesterol (LDL-C), fasting blood glucose (PBG), 2-h postprandial blood glucose (2h PG), and high-sensitive C reaction protein (hs-CRP) (all p < .05). Stratified analysis showed that there was a positive relationship between C1q and the associated factors of acute ischemic stroke for partial LDL-C, and hs-CRP strata. Logistic model analysis suggested that C1q was an independent risk factor for acute ischemic stroke in patients with T2DM. After adjusting for potential confounders, a one-standard deviation (SD) increase in C1q level was strongly related to an approximately 1.5-fold increased risk of acute ischemic stroke in cases with a hs-CRP ≥1.78 mg/L.
Conclusion:
In DAIS patients, the levels of C1q were increased significantly and were an independent associated factor which affected the occurrence of acute ischemic stroke.
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