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Updated: Jul 19, 2025
13:08
Expansion of Human Peripheral Blood γδ T Cells using Zoledronate
Published on: September 9, 2011
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A Rare Presentation of Zoledronate-Induced Systemic Inflammatory Response
Maria Jamil1, Amir Daneshvar1, Dana Nachawati1
1Internal Medicine, Henry Ford Health System, Detroit, USA.
Cureus
|August 8, 2023
Summary
A rare severe immune reaction, including limb weakness, occurred in an 82-year-old woman after zoledronic acid infusion for osteoporosis. Prednisone treatment improved symptoms, suggesting an immune response to the bisphosphonate.
Area of Science:
- Immunology
- Pharmacology
- Rheumatology
Background:
- Zoledronic acid is a widely used bisphosphonate for bone loss conditions.
- While generally safe, rare severe inflammatory reactions can occur.
- Osteoporosis treatment requires careful monitoring for adverse effects.
Observation:
- An 82-year-old female experienced severe limb weakness and tenderness one week post-zoledronic acid infusion for osteoporosis.
- Symptoms progressed, causing functional impairment and requiring a walker.
Findings:
- Laboratory results showed elevated erythrocyte sedimentation rate; other autoimmune markers were normal.
- Improvement with prednisone taper suggested an immune-mediated adverse reaction.
- Polymyalgia rheumatica was considered in the differential diagnosis.
Implications:
- This case underscores the importance of considering severe immune reactions to zoledronic acid.
- Further research is needed to elucidate mechanisms and optimize patient management for bisphosphonate-induced reactions.
Keywords:
bisphosphonateselderly patientsimmune mediated reactioninternal medicine and rheumatologyosteoporosis managementzoledronic acidMore Related Videos
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