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Nodular Vasculitis Following Aromatase Inhibitor Therapy for Breast Cancer: A Case Report
Samuel Srinivasan1, Maria Jamil1, Sarine Tahmazian1
1Internal Medicine, Henry Ford Health System, Detroit, USA.
Cureus
|June 15, 2026
Summary
Letrozole therapy for breast cancer can rarely cause skin issues. A patient developed erythema induratum, a type of nodular vasculitis, which resolved upon stopping the drug.
Area of Science:
- Oncology
- Dermatology
- Pharmacology
Background:
- Letrozole is an aromatase inhibitor used for hormone receptor-positive breast cancer.
- While generally well-tolerated, letrozole can rarely cause cutaneous adverse effects.
- Nodular vasculitis is an uncommon manifestation associated with letrozole therapy.
