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Updated: Jul 19, 2025

Synthesis of a Thiol Building Block for the Crystallization of a Semiconducting Gyroidal Metal-sulfur Framework
Published on: April 9, 2018
One-Pot, Three-Component Assembly of Sulfides Using a Sulfoxide Reagent as a Sulfur Dication Equivalent
Fumito Saito1, Simon Euteneuer1
1Department of Chemistry, Ludwig Maximilian University, Butenandtstr. 5-13, 81377 Munich, Germany.
Abstract:
We report a one-pot, three-component synthesis of sulfides by exploiting a sulfoxide reagent as a formal sulfur dication equivalent. Our protocol consists of three simple chemical operations involving two Grignard reagents and trimethylsilyl chloride (TMSCl) to sequentially form sulfenate anions, sulfenate esters, and sulfides. We demonstrate a wide range of Grignard reagents to be coupled, thereby allowing the modular, thiol-free synthesis of sulfides including dialkenyl and alkenyl-alkynyl sulfides.
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