Euthyroid Graves' disease. Report of a case observed over a 12-year period

A 49-year-old woman had proptosis and inflammation occurring in each eye on separate occasions over a 12-year period. Results of thyroid function studies were normal. Thyroid antibodies, microsomal and thyroglobulin, were not demonstrable. Thyroid-stimulating immunoglobulins were not demonstrable. Thyrotropin-releasing hormone testing showed a normal response. Results of computed axial tomographic scanning of the orbits were normal. The patient had a response on each occasion to prednisone. This patient with euthyroid Graves' disease supports the hypothesis that Graves' eye disease and Graves' hyperthyroidism are distinct and separate entities.