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Lithium-associated thyrotoxicosis.

M T McDermott, K D Burman, F D Hofeldt

The American Journal of Medicine

|June 1, 1986

Summary

This summary is machine-generated.

Lithium carbonate treatment for manic-depressive illness can lead to hypothyroidism and subsequent hyperthyroidism. This case highlights lithium

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Area of Science:

Endocrinology
Psychiatry

Background:

Lithium carbonate is a common treatment for manic-depressive illness.
Thyroid dysfunction is a known side effect of lithium therapy.

Observation:

A 57-year-old woman developed hypothyroidism after 8 years of lithium treatment.
Nine months later, she experienced thyrotoxicosis.

Findings:

Autoimmune disease was suspected as the cause, but lithium's role was considered contributory.
This is the first reported case of hyperthyroidism following hypothyroidism in a lithium-treated patient.

Implications:

Lithium may play a role in both hypothyroid and hyperthyroid phases of thyroid illness.
Further research is needed to understand the mechanisms of lithium-associated thyrotoxicosis.