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Time-restricted eating for chronodisruption-related chronic diseases
Wai-Yin Cheng1, Louis Desmet1, Inge Depoortere1
1Translational Research Center for Gastrointestinal Disorders, Gut Peptide Research Lab, University of Leuven, Leuven, Belgium.
Acta Physiologica (Oxford, England)
|August 9, 2023
Summary
Time-restricted eating (TRE) aligns eating with circadian rhythms, offering health benefits beyond weight management. This dietary strategy impacts metabolism, gut health, and disease risk by optimizing the body's internal clocks.
Area of Science:
- Chronobiology and Metabolic Health
- Nutritional Science and Circadian Rhythms
Background:
- The body's internal circadian timing system regulates physiology and behavior in response to environmental cycles.
- Chronodisruption, a misalignment of circadian rhythms, is linked to metabolic disorders, cardiovascular diseases, and cancer.
- Time-restricted eating (TRE) and time-restricted feeding (TRF) are dietary strategies involving eating within a specific daily window.
Purpose of the Study:
- To review the multifaceted health effects of TRE/TRF.
- To explore the role of circadian clocks in mediating TRE/TRF benefits.
- To suggest optimal TRE strategies for maximizing health outcomes.
Main Methods:
- Literature review of studies on TRE/TRF and circadian biology.
- Analysis of TRE/TRF effects on energy metabolism.
- Examination of TRE/TRF impacts on gut microbiota, cardiovascular health, and cancer development.
Main Results:
- TRE/TRF influences energy metabolism and gut homeostasis.
- Evidence suggests TRE/TRF may mitigate risks associated with cardiovascular diseases and cancer.
- Circadian clocks play a crucial role in mediating the beneficial effects of TRE/TRF.
Conclusions:
- TRE is a promising dietary strategy with broad health implications, extending beyond weight management.
- Optimizing TRE by considering circadian clock function can enhance its therapeutic potential.
- Further research is needed to fully elucidate the mechanisms and optimal application of TRE.
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