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Systemic Inflammation Disrupts Circadian Rhythms and Diurnal Neuroimmune Dynamics
Wai-Yin Cheng1,2,3, Po-Lam Chan2, Hang-Yin Ong1,2
1Department of Food Science and Nutrition, Faculty of Science, The Hong Kong Polytechnic University, Hong Kong SAR, China.
International Journal of Molecular Sciences
|July 13, 2024
Summary
Systemic inflammation disrupts circadian rhythms in the brain and liver. This disruption affects microglia, potentially linking inflammation to neurodegenerative diseases.
Area of Science:
- Neuroscience
- Immunology
- Chronobiology
Background:
- Circadian rhythms govern 24-hour physiological cycles, and disruptions are linked to diseases.
- The interplay between inflammation and circadian rhythms is not fully understood.
Purpose of the Study:
- To investigate how systemic inflammation impacts central and peripheral circadian rhythms.
- To examine the effects of inflammation on diurnal neuroimmune dynamics.
Main Methods:
- Mice were administered lipopolysaccharide (LPS) or saline.
- Diurnal expression of clock genes and inflammatory cytokines was measured in the hypothalamus, hippocampus, and liver.
- Microglial dynamics were assessed over a diurnal cycle.
Main Results:
- Lipopolysaccharide (LPS) disrupted circadian gene oscillations in the hypothalamus, hippocampus, and liver.
- Systemic inflammation induced by LPS triggered neuroinflammation.
- The diurnal behavior of microglia in the hippocampus was perturbed.
Conclusions:
- Systemic inflammation significantly disrupts circadian rhythms across multiple tissues.
- Inflammation-induced circadian disruption is associated with neuroinflammation and altered microglial activity.
- These findings highlight the critical link between inflammation and circadian disruption in the context of neurodegenerative diseases.
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