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Updated: Jul 19, 2025
07:02
Exploring the Arginine Methylome by Nuclear Magnetic Resonance Spectroscopy
Published on: December 16, 2021
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Coactivator-associated arginine methyltransferase 1: A versatile player in cell differentiation and development
Zhongrui Ma1,2, Xinxing Lyu1,3, Ning Qin3
1Medical Research Center, The First Affiliated Hospital of Shandong First Medical University, Jinan, Shandong 250014, China.
Genes & Diseases
|August 9, 2023
Summary
Coactivator-associated arginine methyltransferase 1 (CARM1) regulates gene transcription by methylating proteins. This review details CARM1
Area of Science:
- Biochemistry
- Molecular Biology
- Epigenetics
Background:
- Protein arginine methylation is a crucial post-translational modification regulating cellular functions.
- Coactivator-associated arginine methyltransferase 1 (CARM1) is a key enzyme in this process, modifying histone and non-histone proteins.
- CARM1's diverse roles include regulating gene transcription, cell differentiation, and DNA replication.
Purpose of the Study:
- To elucidate the molecular characteristics of CARM1.
- To review the significant roles of CARM1 in mammalian cell differentiation and development.
Main Methods:
- Literature review of studies on CARM1.
- Analysis of CARM1's enzymatic activity and substrate interactions.
- Synthesis of findings on CARM1's involvement in developmental processes.
Main Results:
- CARM1 asymmetrically dimethylates histone H3 and non-histone proteins.
- CARM1 influences multiple cellular processes including transcription, cell cycle, metabolism, and RNA processing.
- CARM1 is integral to mammalian cell differentiation and development.
Conclusions:
- CARM1 is a multifunctional enzyme with critical roles in gene regulation and cellular processes.
- Understanding CARM1's function is vital for comprehending mammalian development and differentiation.
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