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mRNA-activated DNAzyme nanoprobe for tumor cell precise imaging and gene therapy
Mingzhu Fan1, Huakui Huang2, Yang Xu1
1Guangxi Key Lab of Agricultural Resources Chemistry and Biotechnology, College of Chemistry and Food Science, Yulin Normal University, Yulin, China. shulonghs@163.com.
Analytical Methods : Advancing Methods and Applications
|August 9, 2023
Abstract:
A novel Au-nucleic acid nanoprobe, catalyzed by mRNA, has been developed for live cell imaging and precise treatment of tumor cells. This nanoprobe exhibits the remarkable ability to differentiate between tumor cells and normal cells through live cell mRNA imaging, while selectively inducing apoptosis in tumor cells.
