Related Experiment Video

Updated: Jul 19, 2025

Povidone Iodine Rectal Preparation at Time of Prostate Needle Biopsy is a Simple and Reproducible Means to Reduce Risk of Procedural Infection
05:32

Povidone Iodine Rectal Preparation at Time of Prostate Needle Biopsy is a Simple and Reproducible Means to Reduce Risk of Procedural Infection

Published on: September 21, 2015

32.3K

Prophylactic antibiotics has no benefit for outcome in clean myringoplasty-A register-based cohort study from SwedEar

Eva Westman1, Maria Höglund2, Frida Brännström Nilsson2

  • 1Department of Clinical Sciences, Otorhinolaryngology, Umeå University, Sundsvall, Sweden.

Clinical Otolaryngology : Official Journal of ENT-UK ; Official Journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery
|August 9, 2023
PubMed
Abstract

Insights

Prophylactic antibiotics (PA) do not improve tympanic membrane (TM) healing rates after myringoplasty. PA also did not reduce postoperative infections, though infections did negatively impact TM healing.

Area of Science:

  • Otolaryngology
  • Surgical Infection Prevention

Background:

  • Myringoplasty is a common surgical procedure for tympanic membrane (TM) perforation.
  • The role of prophylactic antibiotics (PA) in improving outcomes for clean myringoplasty remains debated.

Purpose of the Study:

  • To evaluate if prophylactic antibiotics (PA) reduce postoperative infections within 6 weeks after myringoplasty.
  • To determine if PA affects tympanic membrane (TM) healing rates at 6-24 months post-surgery.

Main Methods:

  • Retrospective cohort study utilizing prospectively collected data from the Swedish Quality Register for Ear Surgery (SwedEar) between 2013-2019.
  • Included patients who underwent conventional myringoplasty (tympanoplasty type I) with a registered follow-up visit.
  • Analyzed the impact of PA administration on TM healing and postoperative infection rates.

Main Results:

  • A total of 1665 patients were included; 86.2% achieved TM healing at follow-up.
  • No significant difference in TM healing rates was observed between patients who received PA (87.2%) and those who did not (86.1%).
  • Postoperative infection occurred in 8.0% of patients; rates were 10.2% with PA vs. 7.7% without PA, a difference that was not statistically significant. Postoperative infection was linked to lower TM healing frequency.

Conclusions:

  • Prophylactic antibiotics administered during clean conventional myringoplasty do not enhance TM healing rates.
  • PA use does not decrease the risk of postoperative infection within 6 weeks following myringoplasty.
  • Postoperative infections significantly impede tympanic membrane healing outcomes.
Keywords:
myringoplastypostoperative infectionprophylactic antibioticstympanic membranetympanoplasty

More Related Videos

Author Spotlight: A Novel Protocol for Intracameral Injections to Enhance Precision in Rodent Ophthalmology06:19

Author Spotlight: A Novel Protocol for Intracameral Injections to Enhance Precision in Rodent Ophthalmology

Published on: May 31, 2024

876
PRP as a New Approach to Prevent Infection: Preparation and In vitro Antimicrobial Properties of PRP06:36

PRP as a New Approach to Prevent Infection: Preparation and In vitro Antimicrobial Properties of PRP

Published on: April 9, 2013

21.5K

Related Concept Videos

Chronic Pharyngitis01:23

Chronic Pharyngitis

Chronic pharyngitis refers to persistent inflammation of the pharyngial mucosa.
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...
2.8K
Tonsillitis II: Management01:26

Tonsillitis II: Management

This lesson will focus on the different treatment options for managing tonsillitis, which typically depend on the cause and severity.
135
Healthcare Associated Infections II: Preventive Measures01:22

Healthcare Associated Infections II: Preventive Measures

Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
2.7K
Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
11.9K
Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care01:30

Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care

A healthcare provider can diagnose a urinary tract infection (UTI) through several methods:Medical History and Symptoms: The provider will take a detailed medical history and ask about symptoms such as frequent urination, burning sensation during urination, and lower abdominal pain.Urinalysis: A clean-catch urine sample is collected in a sterile container and tested for the presence of bacteria, white blood cells (leukocytes), nitrites, blood, and protein. The presence of leukocytes and...
15
Treating Helicobacter pylori in Peptic Ulcers: Antimicrobial Therapy01:16

Treating Helicobacter pylori in Peptic Ulcers: Antimicrobial Therapy

Helicobacter pylori, a resilient gram-negative bacterium, can thrive in the stomach's harsh, acidic environment. Infection with H. pylori leads to a cascade of events within the stomach lining. One of the critical disruptions caused by this bacterium is the interference with somatostatin production, a hormone responsible for regulating acid secretion. This interference tips the balance, escalating acid secretion and diminishing bicarbonate levels. This imbalance compromises the defensive...
454