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Oral administration of active vitamin D metabolites to low birthweight infants
Archives of Disease in Childhood
|August 1, 1986
Insights
Active vitamin D metabolites, including 1 alpha, 25-dihydroxycholecalciferol and 1 alpha-hydroxycholecalciferol, are well-absorbed orally in preterm infants. This absorption mirrors patterns observed in adult patients.
Area of Science:
- Biochemistry
- Pediatric Endocrinology
- Pharmacokinetics
Background:
- Vitamin D is crucial for infant health.
- Preterm infants may have altered drug absorption.
- Active vitamin D metabolites are essential for calcium homeostasis.
Purpose of the Study:
- To evaluate the oral absorption of active vitamin D metabolites in preterm infants.
- To compare the absorption patterns in preterm infants to those in adults.
Main Methods:
- Oral administration of 1 alpha, 25-dihydroxycholecalciferol (Rocaltrol) and 1 alpha-hydroxycholecalciferol (One-Alpha).
- Assessment of absorption in preterm infants.
Main Results:
- Both 1 alpha, 25-dihydroxycholecalciferol and 1 alpha-hydroxycholecalciferol showed adequate oral absorption in preterm infants.
- The absorption patterns were comparable to those observed in adult populations.
Conclusions:
- Oral administration of active vitamin D metabolites is effective in preterm infants.
- Preterm infants exhibit similar vitamin D metabolite absorption to adults, supporting therapeutic use.
Abstract:
The active vitamin D metabolites 1 alpha, 25-dihydroxycholecalciferol (Rocaltrol) and the analogue 1 alpha-hydroxycholecalciferol (One-Alpha) are adequately absorbed after oral administration in the preterm infant. The absorption pattern is similar to that seen in adults.