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Carcinoid syndrome. Surgical management.

R B Galland, L H Blumgart

    British Journal of Hospital Medicine
    |March 1, 1986
    PubMed
    Summary

    Carcinoid syndrome affects a small percentage of patients with carcinoid tumors, often presenting with widespread liver metastases. Surgical options are limited, with treatments offering only temporary relief.

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    Area of Science:

    • Oncology
    • Gastroenterology
    • Surgical Oncology

    Background:

    • Carcinoid syndrome affects approximately 5% of patients with carcinoid tumors.
    • Most patients present with diffuse liver metastases, limiting surgical interventions.
    • Current treatments like medical therapy and hepatic dearterialization provide temporary responses.

    Purpose of the Study:

    • To review the limited surgical options for carcinoid syndrome with liver metastases.
    • To highlight cases where liver resection may be a feasible treatment.

    Main Methods:

    • Literature review of carcinoid syndrome and liver metastases.
    • Analysis of treatment outcomes for medical, dearterialization, and surgical approaches.

    Main Results:

    • Diffuse liver metastases are common at initial presentation, restricting surgical candidacy.
    • Medical management and hepatic dearterialization offer transient symptom control.
    • Resection is occasionally possible when liver lesions are confined to a single lobe.

    Conclusions:

    • Surgical resection for carcinoid syndrome with liver metastases is feasible only in select cases with localized disease.
    • Multidisciplinary management is crucial for optimizing outcomes in these complex patients.

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