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How to Report PSMA PET.

Mina Swiha1, Narjess Ayati2, Daniela E Oprea-Lager3

  • 1Department of Theranostics and Nuclear Medicine, St Vincent's Hospital, Sydney, Australia; Nuclear Medicine Division, Department of Medical Imaging, University of Western Ontario, London, Canada.

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This summary is machine-generated.

Prostate-specific membrane antigen positron emission tomography (PSMA-PET) aids in prostate cancer management. Standardized PSMA-PET reporting is crucial for consistent clinical decisions and research translation.

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Area of Science:

  • Oncology
  • Nuclear Medicine
  • Radiology

Background:

  • Prostate cancer (PCa) is a leading cause of cancer morbidity and mortality globally.
  • Prostate-specific membrane antigen positron emission tomography (PSMA-PET) is increasingly vital for PCa staging, recurrence assessment, and treatment eligibility for radioligand therapy (RLT).

Purpose of the Study:

  • To review the clinical utility of PSMA-PET across various stages of prostate cancer.
  • To discuss existing PSMA-PET reporting criteria and identify interpretation pitfalls.
  • To provide recommendations for standardized synoptic reporting of PSMA-PET/CT.

Main Methods:

  • Literature review of PSMA-PET applications in prostate cancer.
  • Analysis of published reporting guidelines and criteria for PSMA-PET.
  • Identification of common challenges and errors in PSMA-PET interpretation and reporting.

Main Results:

  • PSMA-PET is valuable throughout the PCa disease spectrum, from initial staging to recurrent disease management.
  • Current reporting criteria for PSMA-PET vary, necessitating harmonization.
  • Pitfalls in PSMA-PET interpretation can impact clinical decision-making.

Conclusions:

  • Harmonized interpretation and synoptic reporting of PSMA-PET/CT are essential for reproducible communication.
  • Standardized reporting will enhance therapeutic management decisions and facilitate data comparability in clinical trials.
  • This review offers guidance for consistent PSMA-PET reporting to improve clinical practice and research.