Related Experiment Video
Updated: Jul 19, 2025

Real-time Imaging of Axonal Transport of Quantum Dot-labeled BDNF in Primary Neurons
Published on: September 15, 2014
Neuroprotection of Thioredoxin1 in the Brain
Roxana Noriega-Navarro1, Ricardo J Martínez-Tapia1, Juan L Osornio-Hernández1
1Departamento de Fisiología, Facultad de Medicina, Universidad Nacional Autónoma de México, C.P.: 04510, Ciudad de México, México.
None:
Thioredoxin1 (Trx1) is a ubiquitous antioxidant protein that regulates the cell's redox status. Trx1's thiol redox activity protects neurons from various physiological processes that cause neuronal damage and neurodegeneration, including oxidative stress, apoptosis, and inflammation. Several studies have found that direct or indirect Trx1 regulation has neuroprotective effects in the brain, protecting against, preventing, or delaying neurodegenerative processes or brain traumas. This review focuses on the term neuroprotection, Trx1 localization, and expression in the brain, as well as its modulation concerning its neuroprotective effect in both animal and clinical models of ischemia, hypoxia, hemorrhage, traumatic brain injury, epilepsy, Alzheimer's disease, and Parkinson's disease.
Related Concept Videos
The Blood-brain Barrier
Neuroplasticity
Neurogenesis and Regeneration of Nervous Tissue
Enzyme-linked Receptors
Neurotrophin (NT) receptors are a family of RTKs, including trkA, trkB, and trkC (tropomyosin-related kinase) receptors. TrkA is specific for nerve growth factor (NGF), neurotrophin-6, and neurotrophin-7. TrkB binds...
Preparation and Reactions of Thiols

