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A modified hot-plate test sensitive to mild analgesics.

S Hunskaar, O G Berge, K Hole

Behavioural Brain Research

|August 1, 1986

Summary

The modified increasing temperature hot-plate test offers more consistent and sensitive pain measurement in rats and mice compared to the standard constant temperature test. This new method is better for evaluating both narcotic and non-narcotic analgesics.

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Area of Science:

Pharmacology
Neuroscience
Pain Research

Background:

The hot-plate test is a standard method for assessing analgesia.
The conventional constant temperature hot-plate test can be influenced by factors like pre-exposure, affecting response latencies.
A need exists for a more reliable and sensitive analgesimetric test.

Purpose of the Study:

To compare a modified increasing temperature hot-plate test with a standard constant temperature hot-plate test.
To evaluate the reliability and sensitivity of both tests in rats and mice.
To assess the effectiveness of different analgesics using both test paradigms.

Main Methods:

Hindpaw lick was used as the criterion response in both tests.
Experiments involved a standard constant temperature hot-plate test and a modified increasing temperature hot-plate test.
Drug administration included morphine, paracetamol, and acetylsalicylic acid.

Main Results:

The increasing temperature test showed no effect of pre-exposure, unlike the constant temperature test.
Repeated testing yielded consistent responsiveness in both tests and species.
Dose-related increases in response temperature were observed with morphine, paracetamol, and acetylsalicylic acid in the increasing temperature test.
Only morphine consistently affected responses in the constant temperature test.

Conclusions:

The increasing temperature hot-plate test is a valuable analgesimetric tool for rats and mice.
This modified test demonstrates superior consistency and sensitivity to non-narcotic analgesics compared to the conventional hot-plate test.
The increasing temperature hot-plate test provides a more reliable method for pain research and drug evaluation.

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