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A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats

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Published on: May 22, 2019

Poststroke Depression: An Update.

Robert G Robinson¹, Ricardo E Jorge¹, Sergio E Starkstein¹

¹Department of Psychiatry, Carver College of Medicine, University of Iowa, Iowa City (Robinson); Mental Health Service Line, Michael E. DeBakey Veterans Affairs Medical Center, and Division of Neuropsychiatry, Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston (Jorge); Department of Psychiatry, University of Western Australia, Perth, Australia (Starkstein).

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|August 10, 2023

Summary

This summary is machine-generated.

Antidepressants effectively treat and prevent poststroke depression (PSD), improving recovery and long-term survival. Early intervention with these medications is crucial for stroke patients experiencing depression.

Keywords:

Antidepressants Cerebral Vascular Disease Depression Poststroke Depression Selective Serotonin Reuptake Inhibitors Stroke Recovery

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Area of Science:

Neurology
Psychiatry
Clinical Medicine

Background:

Neuropsychiatric disorders following stroke have been documented for over a century.
Systematic research, particularly on poststroke depression (PSD), intensified in the 1970s.
Significant advancements have been made in PSD treatment and prevention.

Purpose of the Study:

To review the efficacy of antidepressants in treating and preventing poststroke depression.
To explore the potential benefits of early PSD treatment on stroke recovery and survival.

Main Methods:

Meta-analyses of randomized controlled trials (RCTs) for PSD treatment.
RCTs evaluating antidepressants for PSD prevention compared to placebo.
Review of studies on long-term outcomes, including physical and cognitive recovery and survival.

Main Results:

Antidepressants demonstrate efficacy in treating established PSD.
Antidepressants significantly reduce the incidence of PSD compared to placebo.
Early antidepressant treatment may enhance physical and cognitive recovery and improve survival up to 10 years post-stroke.

Conclusions:

Antidepressants are effective for both treating and preventing poststroke depression.
Early intervention with antidepressants offers significant benefits for stroke recovery and long-term prognosis.
Further research into etiological factors like genetics and neurobiology is warranted.