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Advances in targeted therapy and immunotherapy for melanoma (Review)

Ziyao Qin1, Mei Zheng1

  • 1No. 4 Research Laboratory, Shanghai Institute of Biological Products Co., Ltd., Shanghai 200051, P.R. China.

Experimental and Therapeutic Medicine
|August 10, 2023
PubMed

Insights

New targeted therapies and immunotherapies have emerged for metastatic melanoma. This review examines clinical trials of these treatments and their combinations to improve outcomes for advanced skin cancer.

Area of Science:

  • Oncology
  • Dermatology
  • Cancer Research

Background:

  • Melanoma is an aggressive skin cancer with a poor prognosis upon metastasis.
  • Recent advancements include FDA-approved targeted agents (BRAF/MEK inhibitors) and immunotherapies (CTLA-4, PD-1/PD-L1 blockade).

Purpose of the Study:

  • To review clinical trials of targeted therapy and immunotherapy for metastatic melanoma.
  • To explore novel combination approaches and upcoming strategies to enhance treatment efficacy.

Main Methods:

  • Review of recent clinical trials and literature on metastatic melanoma treatments.
  • Analysis of targeted therapy, immunotherapy, and combination strategies.

Main Results:

  • Significant progress in metastatic melanoma treatment since 2011 with new targeted and immune agents.
  • Emerging data on the efficacy of combining targeted therapy and immunotherapy.

Conclusions:

  • Combination therapies hold promise for improving outcomes in metastatic melanoma.
  • Ongoing research focuses on optimizing these treatments for better patient survival.
Keywords:
combination therapyimmunotherapymelanomatargeted therapy

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