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Beyond Animal Testing Index: Benchmarking tool for a world beyond animal testing.

Cyrille Krul1, Annick De Moor2, Koen Stegmeijer2

  • 1University of Applied Sciences, HU, Utrecht, The Netherlands.

ALTEX
|August 10, 2023
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Summary
This summary is machine-generated.

The Beyond Animal Testing Index (BATI) is a new tool to benchmark research institutes on their progress toward animal-free innovation. It helps organizations learn, improve strategies, and identify gaps in 3R technologies.

Keywords:
3Rsbenchmarknew approach methodologies (NAMs)transitiontransparency

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Area of Science:

  • * Scientific innovation and research methodologies.
  • * Toxicology and predictive modeling.
  • * Animal welfare and ethical research practices.

Background:

  • * The definition of 'replacement' in scientific research has evolved from solely substituting animal use to embracing advanced, animal-free predictive models.
  • * Transitioning to animal-free innovation is a key political objective globally, particularly within the European Union.
  • * Existing benchmarking tools, like the Access to Medicine Index, provide a model for evaluating progress in complex scientific and societal transitions.

Purpose of the Study:

  • * To introduce the Beyond Animal Testing Index (BATI) as a novel benchmarking instrument for research institutions.
  • * To assess the BATI's utility in evaluating contributions to animal-free innovation.
  • * To stimulate institutional learning and strategic improvement in adopting 3R (Replace, Reduce, Refine) technologies.

Main Methods:

  • * Development of the Beyond Animal Testing Index (BATI), modeled after the Access to Medicine Index.
  • * Field-testing a prototype of the BATI with five Dutch academic institutions (three medical centers, two universities) between 2020-2021.
  • * Analysis of institutional activities and contributions across five distinct domains related to animal-free innovation.

Main Results:

  • * The BATI prototype field test confirmed its usability and effectiveness as a benchmarking tool.
  • * Participating institutions reported that the BATI served as a significant internal and external motivator for sharing knowledge and enhancing strategies for animal-free innovation.
  • * The BATI successfully identified specific areas needing improvement in the development and implementation of 3R technologies.

Conclusions:

  • * The Beyond Animal Testing Index (BATI) is a validated and effective tool for benchmarking research institutes' progress in animal-free innovation.
  • * BATI Version 1.0 is ready for broader application in assessing and promoting the transition to animal-free research.
  • * The index demonstrates potential as a policy monitoring instrument to track the effectiveness of initiatives supporting 3R technologies.