Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Myasthenia Gravis: Diagnostic Tests

Myasthenia Gravis: Diagnostic Tests

Myasthenia gravis is an autoimmune condition affecting neuromuscular transmission, causing generalized weakness in skeletal muscles. Initial diagnoses rely on patients' signs, symptoms, and medical history. The challenge lies in distinguishing myasthenia from other muscular dystrophies. An important diagnostic feature is the significant improvement of symptoms after administering anticholinesterase inhibitors.
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The Relationship Between Sustained Gripping and the Development of Carpal Tunnel Syndrome.

Federal practitioner : for the health care professionals of the VA, DoD, and PHS·2019

Same author

The Assessment and Management of Peripheral Nerve Trauma.

Current treatment options in neurology·2018

Same author

The distribution of neuralgic amyotrophy lesions is overwhelmingly extraplexal.

Muscle & nerve·2018

Same author

The thoracic outlet syndromes: Part 1. Overview of the thoracic outlet syndromes and review of true neurogenic thoracic outlet syndrome.

Muscle & nerve·2016

Same author

The thoracic outlet syndromes: Part 2. The arterial, venous, neurovascular, and disputed thoracic outlet syndromes.

Muscle & nerve·2016

Same author

Lesion distribution among 281 patients with sporadic neuralgic amyotrophy.

Muscle & nerve·2016

Same journal

Preface.

Handbook of clinical neurology·2026

Same journal

Foreword.

Handbook of clinical neurology·2026

Same journal

Fundus autofluorescence imaging.

Handbook of clinical neurology·2026

Same journal

The electroretinogram as a means to study the physiology of the retina.

Handbook of clinical neurology·2026

Same journal

Adaptive optics scanning light ophthalmoscopy.

Handbook of clinical neurology·2026

Same journal

Modeling the human retina in a dish: Advances and future directions.

Handbook of clinical neurology·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jul 19, 2025

Measuring Neuromuscular Junction Functionality

Measuring Neuromuscular Junction Functionality

Published on: August 6, 2017

Neuromuscular electrodiagnosis.

Mark A Ferrante¹

¹Electromyography Laboratory, Department of Neurology, Veterans Administration Medical Center, University of Tennessee, Memphis, TN, United States.

Handbook of Clinical Neurology

|August 10, 2023

Summary

This summary is machine-generated.

Electrodiagnostic (EDX) studies, including nerve conduction studies (NCS) and needle electromyography (EMG), are crucial for diagnosing nerve and muscle disorders. This review focuses on key concepts for lesion localization and characterization.

Keywords:

Electrodiagnostic Electromyography Motor nerve conduction studies Motor unit action potentials Needle EMG Nerve conduction studies Neuromuscular medicine Sensory nerve conduction studies

More Related Videos

Assessment of Neuromuscular Function Using Percutaneous Electrical Nerve Stimulation

Assessment of Neuromuscular Function Using Percutaneous Electrical Nerve Stimulation

Published on: September 13, 2015

Levator Auris Longus Preparation for Examination of Mammalian Neuromuscular Transmission Under Voltage Clamp Conditions

Levator Auris Longus Preparation for Examination of Mammalian Neuromuscular Transmission Under Voltage Clamp Conditions

Published on: May 5, 2018

Related Experiment Videos

Last Updated: Jul 19, 2025

Measuring Neuromuscular Junction Functionality

Measuring Neuromuscular Junction Functionality

Published on: August 6, 2017

Assessment of Neuromuscular Function Using Percutaneous Electrical Nerve Stimulation

Assessment of Neuromuscular Function Using Percutaneous Electrical Nerve Stimulation

Published on: September 13, 2015

Levator Auris Longus Preparation for Examination of Mammalian Neuromuscular Transmission Under Voltage Clamp Conditions

Levator Auris Longus Preparation for Examination of Mammalian Neuromuscular Transmission Under Voltage Clamp Conditions

Published on: May 5, 2018

Area of Science:

Neurology
Neurophysiology

Background:

Electrodiagnostic (EDX) studies are extensions of clinical examinations, guiding initial nerve conduction studies (NCS).
Competent EDX study performance requires specialized knowledge and training, encompassing anatomical, physiological, pathological, and electrical principles.

Approach:

Focuses on standard NCS and needle EMG measurements for lesion localization and characterization.
Emphasizes motor unit action potential analysis as a challenging yet critical component.
Reviews the utility of sensory NCS for focal axon loss and motor NCS for demyelination and severity assessment.

Key Points:

NCS and needle EMG are essential for confirming findings, refining localization, and determining lesion chronicity and progression.
Sensory NCS identify focal axon loss.
Motor NCS screen for focal demyelination and assess lesion severity.

Conclusions:

EDX studies, particularly NCS and needle EMG, are indispensable tools in clinical neurology.
Understanding core concepts enhances diagnostic accuracy in peripheral nerve disorders.
Motor unit action potential analysis is key for comprehensive EDX evaluation.