Related Experiment Video
Updated: Jul 19, 2025
16:15
Mouse Kidney Transplantation: Models of Allograft Rejection
Published on: October 11, 2014
20.7K
Kidney Allograft Rejection and Coronavirus Disease 2019 Infection: A Narrative Review
Seyed Amirhossein Fazeli1, Amirhesam Alirezaei1, Amirhossein Miladipour1
1Department of Nephrology, Clinical Research and Development Center at Shahid Modarres Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Advanced Biomedical Research
|August 11, 2023
Summary
The coronavirus disease 2019 (COVID-19) pandemic impacts kidney transplant recipients. This review examines COVID-19
Area of Science:
- Nephrology and Transplant Immunology
- Infectious Diseases and Public Health
Background:
- The COVID-19 pandemic has caused significant global health and economic challenges.
- COVID-19 is a systemic illness that can affect multiple organs, including the kidneys.
- Existing research documents COVID-19's impact on acute kidney injury and kidney disease patients.
Purpose of the Study:
- To review current studies on kidney transplant recipients with COVID-19.
- To analyze the incidence of kidney allograft rejection in these patients.
- To discuss immunosuppression management, rejection risk factors, and outcomes.
Main Methods:
- Systematic review of current literature.
- Analysis of studies focusing on kidney transplant recipients diagnosed with COVID-19.
- Examination of data on allograft rejection, immunosuppression, donor-specific antibodies, and rejection history.
Main Results:
- Reports indicate various COVID-19 related kidney conditions in transplant patients.
- Specific focus on kidney allograft rejection incidence and outcomes.
- Evaluation of immunosuppression strategies and their association with rejection risk.
Conclusions:
- COVID-19 presents unique challenges for kidney transplant recipients.
- Understanding rejection incidence, risk factors, and outcomes is crucial for patient management.
- Further research is needed to optimize care for this vulnerable population.
Related Concept Videos
01:28Kidney Transplant I: Introduction
29
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
29
01:26Kidney Transplant II: Surgical Procedure
36
Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
36
01:16Kidney Transplant III: Nursing Management
39
Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
39
01:22Acute Kidney Injury I: Introduction
30
Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...
30
01:29Acute Kidney Injury II: Pathophysiology
30
Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
30
01:30Acute Kidney Injury IV: Diagnostic Studies and Prevention
35
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
35