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Related Experiment Videos

Body surface potential mapping in ischemic patients with normal resting ECG.

D Stilli, E Musso, E Macchi

    The Canadian Journal of Cardiology
    |July 1, 1986
    PubMed
    Summary

    Body surface mapping detects subtle cardiac electrical changes in ischemic heart disease patients, even with normal electrocardiograms. This non-invasive technique aids in identifying myocardial ischemia not visible on standard ECGs.

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    American journal of physiology. Heart and circulatory physiology·2016

    Area of Science:

    • Cardiology
    • Biomedical Engineering
    • Electrophysiology

    Background:

    • Ischemic heart disease (IHD) often presents with normal resting 12-lead electrocardiograms (ECGs).
    • Standard ECGs may fail to detect electrophysiological abnormalities indicative of myocardial ischemia.
    • Advanced diagnostic tools are needed to identify IHD in patients with non-diagnostic ECGs.

    Purpose of the Study:

    • To investigate the utility of body surface mapping (BSM) in detecting cardiac electrogenesis alterations in IHD patients.
    • To determine if BSM can identify abnormalities in patients with normal resting ECGs.
    • To assess the diagnostic accuracy of BSM for myocardial ischemia.

    Main Methods:

    • Recorded body surface potential maps (BSMs) from 14 IHD patients (Group A: normal ECG, Group B: abnormal ECG) and 36 healthy controls.

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  • Analyzed ST-T segment abnormalities in BSM data, focusing on potential minimum location, time functions (Mxi, delta Vi, integral of |Vi|dS).
  • Applied Fisher's discriminant analysis using 10 selected BSM variables for classification.

    • Main Results:

    • Ischemic patients exhibited anomalous potential minimum locations and/or reduced instantaneous values of key time functions.
    • These BSM abnormalities were present in both Group A and Group B patients, suggesting an ischemic origin.
    • Fisher's discriminant analysis achieved >90% correct classification, validated at 80.9% with a test set.

    Conclusions:

    • Resting body surface mapping can reveal altered cardiac electrogenesis in myocardial ischemia.
    • BSM identifies electrophysiological changes not apparent on standard 12-lead ECGs.
    • BSM demonstrates high diagnostic accuracy for detecting myocardial ischemia, particularly in patients with normal ECGs.