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Related Concept Videos

EPS and iPS Cells in Disease Research01:21

EPS and iPS Cells in Disease Research

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Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
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Tissue Renewal without Stem Cells01:23

Tissue Renewal without Stem Cells

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After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...
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Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

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The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
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Unrenewable Cells00:50

Unrenewable Cells

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In humans, the photoreceptor cells of the eye and sensory hair cells of the ear lack stem cells. These cells are thus unrenewable and cannot be replaced when they are damaged or destroyed.
Photoreceptors
The retina is composed of several layers and contains specialized cells called photoreceptors. The photoreceptors (rods and cones) change their membrane potential when stimulated by light energy. There are two types of photoreceptors—rods and cones—which differ in the shape of...
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Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

9
Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs but also impacts other areas, such as the arms, thereby impairing overall circulation and organ function.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty deposits inside the arterial...
9
iPS Cell Differentiation01:22

iPS Cell Differentiation

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The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
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Related Experiment Video

Updated: Jul 19, 2025

A High Output Method to Isolate Cerebral Pericytes from Mouse
06:49

A High Output Method to Isolate Cerebral Pericytes from Mouse

Published on: January 14, 2020

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Pericyte Loss in Diseases.

Pengfei Li1, Hongkuan Fan1

  • 1Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC 29425, USA.

Cells
|August 11, 2023
PubMed
Summary

Pericyte loss is linked to diseases like Alzheimer's and stroke. This review covers how to detect pericyte loss, its causes, and potential treatments to preserve their function.

Area of Science:

  • Vascular biology
  • Cell biology
  • Pathology

Background:

  • Pericytes are crucial microvascular cells supporting endothelial cells.
  • They regulate blood flow, vessel stability, and the blood-brain barrier.
  • Pericyte loss is implicated in neurological and systemic diseases.

Purpose of the Study:

  • To review methods for detecting pericyte loss.
  • To explore mechanisms driving pericyte loss in disease.
  • To discuss current and future pericyte-targeted therapies.

Main Methods:

  • Literature review of studies on pericyte loss.
  • Analysis of techniques for assessing pericyte coverage.
  • Examination of disease-specific pericyte pathology.
Keywords:
blood–brain barrierdiabetesperictyesvascular leak

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Related Experiment Videos

Last Updated: Jul 19, 2025

A High Output Method to Isolate Cerebral Pericytes from Mouse
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3D Visualization of Retinal Vascular Pericytes in Mice by Immunostaining
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Main Results:

  • Pericyte loss is a common feature in diabetes, Alzheimer's, sepsis, stroke, and TBI.
  • Various methods exist to quantify pericyte coverage, including immunohistochemistry and imaging.
  • Multiple pathways contribute to pericyte dysfunction and loss.

Conclusions:

  • Understanding pericyte loss mechanisms is key for disease intervention.
  • Therapeutic strategies aim to protect pericytes and restore vascular integrity.
  • Targeting pericytes offers a promising avenue for treating diverse pathologies.