Better safe than sorry: Oxytocin shifts the regulatory focus

Oxytocin (OT) is known to play a major role in social cognition and behavior. In this study, we aimed to investigate whether OT also affects the motivational system, specifically, the regulatory focus. Because OT weakens the self- and promotes the other-bias, we hypothesized that OT would decrease promotion focus and increase prevention focus. To test this, we conducted two experiments. In each, male participants intranasally administered OT or a placebo and assessed their regulatory focus using validated paradigms. Results revealed that OT led to an increase of prevention focus (Studies 1 and 2) and a slight but non-significant decrease of promotion focus (Study 2). Thus, participants under OT (vs. placebo) saw potential losses as more important, while they tended to devaluate potential gains. This was unrelated to the perceived likelihood of success. These findings indicate that OT might provide adaption to the social environment by pursuing a vigilant motivational strategy.