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Surface Functionalization of Hepatitis E Virus Nanoparticles Using Chemical Conjugation Methods

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Published on: May 11, 2018

Viral protein-based nanoparticles (part 2): Pharmaceutical applications.

Rocio Mellid-Carballal¹, Sara Gutierrez-Gutierrez¹, Carmen Rivas²

¹CiMUS Research Center, Universidad de Santiago de Compostela, Spain; Department of Pharmacology, Pharmacy and Pharmaceutical Technology, Universidad de Santiago de Compostela, Spain.

European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences

|August 11, 2023

Summary

Viral protein nanoparticles (ViP NPs) offer safe and effective alternatives to traditional vaccines and synthetic nanoparticles. These biocompatible structures show promise in prophylaxis, diagnosis, and treatment, with several VLP- and virosome-based vaccines already authorized.

Keywords:

Diagnostics Drug delivery Immunostimulation Vaccines Virosomes Virus-like particles

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Area of Science:

Biotechnology
Nanomedicine
Vaccinology

Background:

Viral protein nanoparticles (ViP NPs) bridge the gap between viruses and synthetic nanoparticles.
They possess inherent biocompatibility and biodegradability, unlike many synthetic counterparts.
ViP NPs avoid the safety concerns associated with viral genomes.

Conclusions:

ViP NPs offer a versatile platform for pharmaceutical applications across disease management.
Their unique properties enable advancements in vaccination, drug delivery, and diagnostics.
Continued research is expanding the therapeutic and diagnostic potential of ViP NPs.