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Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...

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Correction: Kuc et al. Tension-Dominant Orthodontic Loading and Buccal Periodontal Phenotype Preservation: An Integrative Mechanobiological Model Supported by FEM and a Proof-of-Concept CBCT. <i>J. Funct. Biomater.</i> 2026, <i>17</i>, 47.

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Formulation of Diblock Polymeric Nanoparticles through Nanoprecipitation Technique
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Polyphosphazene-Based Nanotherapeutics.

Sara Gutierrez-Gutierrez1,2, Rocio Mellid-Carballal1,2, Noemi Csaba1,2

  • 1Department of Pharmacology, Pharmacy and Pharmaceutical Technology, CiMUS Research Centre, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain.

Journal of Functional Biomaterials
|August 27, 2025
PubMed
Summary
This summary is machine-generated.

Poly(organo)phosphazenes (PPZs) are advanced biomaterials for nanomedicine drug delivery. Their tunable structure enhances biocompatibility, enabling targeted delivery and controlled release for improved therapeutic outcomes.

Keywords:
PPZschemistrydrug-conjugatesmicellespharmaceutical propertiespoly(organo)phosphazenespolyelectrolytic complexespolymersomes

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Area of Science:

  • Biomaterials Science
  • Nanomedicine
  • Polymer Chemistry

Background:

  • Poly(organo)phosphazenes (PPZs) are hybrid polymers with an inorganic backbone and organic side chains.
  • Their unique structure offers tunable properties, biocompatibility, and adaptability for biomedical applications.

Purpose of the Study:

  • To review the chemistry, biopharmaceutical characteristics, and applications of PPZs in nanomedicine.
  • To highlight PPZs as a versatile platform for advanced drug delivery systems.

Main Methods:

  • Exploration of PPZ synthesis and functionalization for nanostructure formation.
  • Analysis of drug-loading mechanisms including electrostatic complexation, self-assembly, and covalent conjugation.
  • Review of PPZ applications in zero-dimensional nanotherapeutics and nanoparticle formulations.

Main Results:

  • PPZs exhibit tunable properties for enhanced drug stability, targeted delivery, and controlled release.
  • Engineered PPZ nanostructures effectively address limitations of conventional drug delivery systems.
  • Various drug-loading strategies demonstrate the versatility of PPZs for therapeutic applications.

Conclusions:

  • PPZs represent a promising next-generation biomaterial for sophisticated drug delivery platforms.
  • Their adaptability and biocompatibility position them as key components in future nanomedicine advancements.
  • PPZ-based nanotherapeutics offer significant potential for improving treatment efficacy and patient outcomes.