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[Lofepramine: a comparative clinical study with amitriptyline].

J Mariategui, H Chávez, A Olivares

    Acta Physiologica Latino Americana
    |September 1, 1978
    PubMed
    Summary
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    Lofepramine and amitriptyline showed similar therapeutic effects in treating depression. Lofepramine may offer benefits for neurotic depression and patients sensitive to anticholinergic side effects.

    Area of Science:

    • Psychiatry
    • Pharmacology
    • Clinical Research

    Background:

    • Lofepramine is a novel tricyclic antidepressant with a favorable pharmacological profile.
    • It exhibits low toxicity, reduced anticholinergic effects, and good tolerance compared to other tricyclic antidepressants.
    • High plasma concentration levels and efficient elimination are noted.

    Purpose of the Study:

    • To compare the efficacy and side-effect profile of lofepramine with amitriptyline.
    • To evaluate therapeutic response in patients with depression using a double-blind study design.

    Main Methods:

    • A double-blind study involving 60 outpatients (5 male, 55 female) aged 16-65 with endogenous or neurotic depression.
    • Equimolar dosages of lofepramine and amitriptyline were administered.

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  • Statistical analysis using the chi-square test was performed on therapeutic response, Hamilton Depression Rating Scale scores, depression type, and side-effects.

    • Main Results:

    • No statistically significant differences were found between lofepramine and amitriptyline in maximal therapeutic response or Hamilton Depression Rating Scale scores.
    • Xerostomy (dry mouth) was a noted side-effect, occurring less frequently with lofepramine.
    • Lofepramine demonstrated a trend towards better outcomes in neurotic depression.

    Conclusions:

    • Lofepramine demonstrates comparable therapeutic efficacy to amitriptyline in the studied outpatient population.
    • Lofepramine appears to be a potentially better option for patients with neurotic depression and those sensitive to anticholinergic adverse effects.
    • Further research may be warranted to confirm these trends.