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Blood-Derived Systemic Inflammation Markers and Risk of Nodal Failure in Stage Ia Non-Small Cell Lung Cancer: A
Federico Tacconi1, Giuseppe Mangiameli2,3, Emanuele Voulaz2,3
1Thoracic Surgery and Breast Unit, Department of Surgical Sciences, Tor Vergata University Polyclinic, Viale Oxford 81, 00133 Rome, Italy.
Systemic inflammation markers like NLR, PLR, and SII do not predict lymph node spread in early-stage non-small cell lung cancer (NSCLC). However, elevated platelet-related markers may influence nodal recurrence in larger tumors post-surgery.
Area of Science:
- Oncology
- Surgical Oncology
- Translational Research
Background:
- Regional lymph node metastasis occurs in up to 10% of early-stage non-small cell lung cancer (NSCLC) patients.
- Systemic inflammation is linked to tumor progression, prompting investigation into blood markers for predicting nodal outcomes.
Purpose of the Study:
- To evaluate if preoperative blood-derived systemic inflammation markers can predict nodal status in stage Ia NSCLC.
- To assess the association between inflammation markers and occult nodal spread or recurrence.
Main Methods:
- Collected preoperative neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and systemic inflammation score (SII) from 368 NSCLC patients.
- Utilized logistic regression and time-event analysis to correlate markers with nodal spread and recurrence.
Main Results:
- No inflammation marker predicted occult nodal spread.
- Systemic inflammation score (SII) showed a marginal association with early nodal recurrence (p=0.065).
- Patients with T1c tumors and elevated PLR/SII experienced significantly shorter times to nodal recurrence (p=0.001).
Conclusions:
- Blood-derived inflammation markers are not valuable for preoperative nodal status prediction in early NSCLC.
- Platelet-related inflammation markers might influence nodal progression in tumors exceeding 2 cm after resection.
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