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Microbial Reprogramming in Obsessive-Compulsive Disorders: A Review of Gut-Brain Communication and Emerging Evidence
Ghizlane Bendriss1, Ross MacDonald1, Clare McVeigh1
1Weill Cornell Medicine Qatar, Doha P.O. Box 24144, Qatar.
International Journal of Molecular Sciences
|August 12, 2023
Summary
Gut dysbiosis, an imbalance in gut microbes, may contribute to obsessive-compulsive disorder (OCD). This review explores the gut-brain axis link and microbial reprogramming as potential OCD treatments.
Area of Science:
- Neuroscience
- Microbiology
- Psychiatry
Background:
- Obsessive-compulsive disorder (OCD) is a mental health condition marked by obsessions and compulsions.
- Gut dysbiosis, an imbalance in gut microbiota, is linked to various health issues, including mental and inflammatory disorders.
Purpose of the Study:
- To review evidence linking gut dysbiosis to OCD's complex causes.
- To explore the gut microbiota as a potential therapeutic target for OCD.
Main Methods:
- Literature review of studies on OCD, gut microbiota, and the gut-brain axis.
- Analysis of proposed models integrating genetic, neurobiological, immunological, and environmental factors with dysbiosis in OCD.
Main Results:
- Growing evidence suggests dysbiosis plays a role in OCD pathophysiology.
- Dysbiosis may act as a unifying factor in the multifactorial etiology of OCD.
Conclusions:
- The gut-brain axis is crucial in understanding and treating OCD.
- Microbial reprogramming strategies (e.g., probiotics, fecal transplants) show promise for novel OCD therapeutics.
- A holistic, personalized approach considering gut-brain interactions is essential for OCD interventions.
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