Related Experiment Video
Updated: Jul 19, 2025
18:30
RNA-seq Analysis of Transcriptomes in Thrombin-treated and Control Human Pulmonary Microvascular Endothelial Cells
Published on: February 13, 2013
22.0K
Long Non-Coding RNAs in Venous Thromboembolism: Where Do We Stand?
Inês Soares Marques1,2, Valéria Tavares1,3,4, Beatriz Vieira Neto1,5
1Molecular Oncology and Viral Pathology Group, Research Center of IPO Porto (CI-IPOP)/Pathology and Laboratory Medicine Dep., Clinical Pathology SV/RISE@CI-IPOP (Health Research Network), Portuguese Oncology Institute of Porto (IPO Porto)/Porto Comprehensive Cancer Centre (Porto.CCC), 4200-072 Porto, Portugal.
International Journal of Molecular Sciences
|August 12, 2023
Summary
Long non-coding RNAs (lncRNAs) show potential in understanding venous thromboembolism (VTE) and coagulation. Further research is needed to explore their role in VTE prediction, prevention, and treatment.
Area of Science:
- Cardiovascular Science
- Molecular Biology
- Genetics
Background:
- Venous thromboembolism (VTE) is a significant cardiovascular disorder caused by hemostatic irregularities.
- Complications from VTE severely impact patient quality of life and can be fatal.
- Long non-coding RNAs (lncRNAs) are increasingly recognized for their potential role in VTE pathogenesis.
Purpose of the Study:
- To review emerging evidence on lncRNAs associated with VTE.
- To explore the role of lncRNAs in the coagulation system's activity.
- To assess the clinical utility of lncRNAs as biomarkers and therapeutic targets for VTE.
Main Methods:
- Literature review of studies investigating lncRNAs and VTE.
- Analysis of identified lncRNAs implicated in VTE pathogenesis.
- Examination of lncRNAs affecting anticoagulant protein expression (e.g., TFPI2).
Main Results:
- Ten lncRNAs have been linked to VTE pathogenesis, with MALAT1 having the most supporting evidence.
- Five lncRNAs were found to influence the expression of the anticoagulant protein TFPI2.
- No lncRNAs have yet been definitively linked to VTE development through TFPI2 modulation.
Conclusions:
- lncRNAs represent a promising area for VTE research.
- Further investigation is required to elucidate the precise role of lncRNAs in VTE pathways.
- lncRNAs may offer future potential for VTE prediction, prevention, and treatment strategies.
Related Concept Videos
01:30Venous Thrombosis I: Introduction
12
Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
12
01:29Venous Thrombosis III: Interprofessional Care
10
Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
10
01:20Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies
14
The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
14
02:39lncRNA - Long Non-coding RNAs
8.6K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
8.6K
01:30Anticoagulant Drugs: Low-Molecular-Weight Heparins
753
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
753
01:30Venous Thrombosis IV: Nursing Management
14
Nursing management begins with a thorough assessment of the patient's health history. Key factors include trauma to veins, peripherally inserted central catheters, varicose veins, recent pregnancy or childbirth, surgery, bacteremia, prolonged bed rest, atrial fibrillation, COPD, heart failure, cancer, coagulation disorders, myocardial infarction, spinal cord injury, stroke, prolonged travel, recent bone fractures, and dehydration. Review medication intake, particularly oral contraceptives,...
14