Vitamin D Receptor rs731236 Polymorphism Modulates Cancer Cachexia Susceptibility and Overall Survival: A Real-World...

Area of Science:

• Oncology
• Genetics
• Metabolic Syndrome

Background:

• Cancer-associated cachexia (CAC) is a debilitating syndrome marked by muscle loss, inflammation, and poor survival.
• Interindividual differences in CAC susceptibility suggest a role for host genetic factors.
• Vitamin D receptor (VDR) signaling is crucial for muscle metabolism and inflammation, pathways relevant to CAC.

Purpose of the Study:

• To investigate the association between the VDR rs731236 (A>G) polymorphism and susceptibility to CAC.
• To examine the impact of this VDR polymorphism on survival outcomes in cancer patients.

Main Methods:

• A cohort of 140 adult cancer patients was analyzed.
• The rs731236 (A>G) polymorphism in the VDR gene was genotyped.
• Statistical analyses included chi-square tests, Log-rank tests, and Tarone-Ware tests.

Main Results:

• The rs731236 GG genotype showed a significant association with a lower prevalence of CAC.
• Patients with the GG genotype exhibited significantly improved survival compared to those with AA/AG genotypes.
• p < 0.05 for all significant findings.

Conclusions:

• The VDR rs731236 polymorphism influences both CAC susceptibility and patient survival.
• These findings highlight a potential clinical role for VDR signaling in supportive cancer care.
• Vitamin D signaling pathways may be a therapeutic target in managing cachexia in cancer patients.