Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: Jul 19, 2025

Establishing 3D Endometrial Organoids from the Mouse Uterus

Establishing 3D Endometrial Organoids from the Mouse Uterus

Published on: January 6, 2023

Engineering the endometrium.

Shelly R Peyton¹

¹Department of Chemical Engineering, University of Massachusetts Amherst, Amherst, MA 01003, USA; Molecular and Cellular Biology Graduate Program, University of Massachusetts Amherst, Amherst, MA 01003, USA; Department of Biomedical Engineering, University of Massachusetts Amherst, Amherst, MA 01003, USA; Institute for Applied Life Sciences, University of Massachusetts Amherst, Amherst, MA 01003, USA.

Med (New York, N.Y.)

|August 12, 2023

Summary

Researchers developed a novel synthetic endometrial model for long-term cell culture. This innovative model simulates the menstrual cycle, aiding the study of reproductive diseases.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Roadmap on biomaterials for women's health.

JPhys materials·2026

Same author

The Intersecting Physical Mechanisms That Regulate Cell Viability in 3D Synthetic Hydrogels.

Advanced materials (Deerfield Beach, Fla.)·2026

Same author

Synthetic living materials in cancer biology.

Nature reviews bioengineering·2026

Same author

MALDI mass spectrometry imaging of extracellular matrix proteins.

The Analyst·2025

Same author

Molecularly Shielded, On-Demand, Ultrasound-Cured Polymer Networks.

Macromolecules·2025

Same author

Cell-Instructive Biomaterials with Native-Like Biochemical Complexity.

Annual review of biomedical engineering·2025

Area of Science:

Reproductive biology and tissue engineering.

Background:

The endometrium undergoes dynamic changes throughout the menstrual cycle, influenced by sex hormones.
Understanding endometrial regeneration is crucial for reproductive health research.

Purpose of the Study:

To present an innovative, synthetic model of the human endometrial environment.
To enable long-term cultures that simulate the 28-day menstrual cycle.

Main Methods:

Development of a synthetic in vitro model mimicking the endometrial microenvironment.
Establishment of conditions supporting long-term endometrial cell culture.

Main Results:

The synthetic model successfully supports long-term endometrial tissue cultures.
The model effectively simulates key aspects of the 28-day menstrual cycle.

More Related Videos

Generation of Multicellular Human Primary Endometrial Organoids

Generation of Multicellular Human Primary Endometrial Organoids

Published on: October 4, 2019

Author Spotlight: Advancing Therapeutic Strategies for Improving Pregnancy Rates by Analyzing Embryo-Endometrium Interactions

Author Spotlight: Advancing Therapeutic Strategies for Improving Pregnancy Rates by Analyzing Embryo-Endometrium Interactions

Published on: June 21, 2024

Related Experiment Videos

Last Updated: Jul 19, 2025

Establishing 3D Endometrial Organoids from the Mouse Uterus

Establishing 3D Endometrial Organoids from the Mouse Uterus

Published on: January 6, 2023

Generation of Multicellular Human Primary Endometrial Organoids

Generation of Multicellular Human Primary Endometrial Organoids

Published on: October 4, 2019

Author Spotlight: Advancing Therapeutic Strategies for Improving Pregnancy Rates by Analyzing Embryo-Endometrium Interactions

Author Spotlight: Advancing Therapeutic Strategies for Improving Pregnancy Rates by Analyzing Embryo-Endometrium Interactions

Published on: June 21, 2024

Conclusions:

This novel synthetic endometrial model offers a valuable tool for reproductive research.
The model can be utilized to investigate reproductive pathophysiology and disease mechanisms.