Related Experiment Video
Updated: Jul 19, 2025
Establishing 3D Endometrial Organoids from the Mouse Uterus
Published on: January 6, 2023
Engineering the endometrium
1Department of Chemical Engineering, University of Massachusetts Amherst, Amherst, MA 01003, USA; Molecular and Cellular Biology Graduate Program, University of Massachusetts Amherst, Amherst, MA 01003, USA; Department of Biomedical Engineering, University of Massachusetts Amherst, Amherst, MA 01003, USA; Institute for Applied Life Sciences, University of Massachusetts Amherst, Amherst, MA 01003, USA.
Abstract:
Endometrial tissue is a dynamic environment that regenerates alongside the menstrual cycle and in response to sex hormones. This month in Med, Gnecco and colleagues1 present an innovative, synthetic model of endometrial environment that supports long-term cultures, simulates a 28-day menstrual cycle, and could be employed to investigate reproductive pathophysiology.
