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Simple In-House Ultra-High Performance Capillary Column Manufacturing with the FlashPack Approach

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Published on: December 4, 2021

Multicapillary columns with ionic liquids as stationary liquid phase.

Yuri V Patrushev¹, Mikhail V Shashkov¹, Vladimir N Sidelnikov²

¹Boreskov Institute of Catalysis, pr. Lavrentieva 5, Novosibirsk 630090, Russia; Novosibirsk State University, Pirogova St. 2, Novosibirsk 630090, Russia.

Journal of Chromatography. A

|August 13, 2023

Summary

Ionic liquids show promise as stationary liquid phases in gas chromatographic multicapillary columns, enabling rapid and selective separations. The study highlights 1,2-Dimethyl-3-propylimidazolium bis(trifluoromethylsulfonyl)imide for high efficiency.

Keywords:

Fast separations Ionic liquids Multicapillary column Stationary phases

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Post Column Derivatization Using Reaction Flow High Performance Liquid Chromatography Columns

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Published on: April 26, 2016

Area of Science:

Analytical Chemistry
Separation Science

Background:

Traditional stationary liquid phases (SLPs) in gas chromatography (GC) face limitations in achieving both high speed and selectivity.
Ionic liquids (ILs) offer unique tunable properties that make them potential candidates for advanced chromatographic applications.

Purpose of the Study:

To investigate the feasibility of using ionic liquids as SLPs in multicapillary columns (MCCs) for gas chromatography.
To evaluate the performance, efficiency, and loading capacity of IL-based MCCs.

Main Methods:

Three classes of ionic liquids (Imidazolium, Pyridinium, Quinolinium) were synthesized and employed as SLPs in MCCs.
The efficiency of the MCCs was analyzed concerning carrier gas flow rate and sample volume.
Loading capacity was determined for the most efficient column.
Separation of fatty acid esters and phenols was performed as a test case.

Main Results:

The study confirmed the viability of ILs as SLPs for GC-MCCs.
1,2-Dimethyl-3-propylimidazolium bis(trifluoromethylsulfonyl)imide (DiMPrIm) exhibited the highest efficiency among the tested ILs.
The performance of the DiMPrIm-based column was further characterized regarding sample volume and loading capacity.
Successful separation of complex mixtures (fatty acid esters, phenols) demonstrated the practical utility of IL-MCCs.

Conclusions:

Ionic liquids are effective SLPs for GC-MCCs, offering a route to enhanced separation performance.
The DiMPrIm-based ionic liquid provides a robust and efficient stationary phase for fast and selective chromatographic separations.
IL-based MCCs represent a significant advancement in chromatographic technology for analyzing complex samples.