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Interrelation of Chronic Lung Disease and Cardiovascular Disease Based on Two National Prospective Cohort Studies
Xueling Ren1, Shengshu Wang2, Junsong Lian3
1Department of Respiratory, National Clinical Research Center for Geriatrics Diseases, The Second Medical Center of Chinese PLA General Hospital, Beijing, China.
Insights
Chronic lung diseases (CLDs) increase cardiovascular disease (CVD) risk in older adults, and vice versa. Body mass index and depression may mediate this link.
Area of Science:
- Public Health
- Epidemiology
- Gerontology
Background:
- Chronic lung diseases (CLDs) and cardiovascular diseases (CVDs) represent a significant global health burden.
- Understanding the interrelation between CLDs and CVDs is crucial for public health strategies.
Purpose of the Study:
- To estimate the interrelation between chronic lung diseases and cardiovascular diseases.
- To investigate potential mediating pathways between CLDs and CVDs in Chinese adults.
Main Methods:
- Utilized two large Chinese national longitudinal cohort studies: CHARLS (n=15,052) and CLHLS (n=9,765).
- Employed Cox proportional risk models to assess the association between CLDs and CVDs.
- Analyzed mediating effects of BMI and depressive symptoms (CES-D-10) on the CLD-CVD relationship.
Main Results:
- CLDs were a significant predictor of incident CVDs (HR 1.49) and CVDs excluding stroke (HR 1.76).
- CVDs were also a significant predictor of CLDs (HR 1.40) in the CHARLS cohort.
- Associations were mediated by Body Mass Index (BMI) and depressive symptoms (CES-D-10 scores).
Conclusions:
- Chronic lung disease is associated with an increased incidence of cardiovascular disease in middle-aged and older community populations, and vice versa.
- Body mass index and depressive symptoms may play a mediating role in the effect of CLD on CVD.
Background:
Chronic lung diseases (CLDs) and cardiovascular diseases (CVDs) are the main chronic diseases responsible for a considerable burden of disease. This study aimed to estimate the interrelation of CLDs and CVDs using two Chinese national longitudinal cohort studies.
Methods:
The China Health and Retirement Longitudinal Study (CHARLS) and Chinese Longitudinal Healthy Longevity Survey (CLHLS) were used in this study with 15,052 and 9,765 participants, respectively. The Cox proportional risk model was used to estimate the interrelation between CLDs and CVDs. Mediating effects were performed to detect possible influencing pathways between CLDs and CVDs.
Results:
The association of CLDs with CVDs was identified in 1,647 participants (10.9%) with newly diagnosed CVDs in CHARLS and 332 participants (11.6%) in CLHLS. The Cox proportional risk model showed that CLDs were a significant predictor of CVDs (HR 1.49, 95% CI 1.27-1.76) after adjusting for covariates, and the hazard ratios of stroke and CVDs excluding stroke were (HR 1.02, 95% CI 0.79-1.31) and (HR 1.76, 95% CI 1.46-2.13), respectively. These association were mediated by body mass index (BMI) and Center for Epidemiological Studies Depression Scale (CES-D-10) scores. No significant association was found in CHARLS and CLHLS regarding CVDs with CLDs. In CHARLS, CVDs was a significant predictor of CLDs (HR 1.40, 95% CI 1.09-1.79).
Conclusions:
Chronic lung disease was associated with increased incidence of CVDs in middle-aged and older people in the community population and vice versa. Body mass index and depressive symptoms might be mediated by the effect of CLD on CVD.
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