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Essential Minerals for Bone Health

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Site-Directed Immobilization of Bone Morphogenetic Protein 2 to Solid Surfaces by Click Chemistry

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Bisphosphonate-incorporated coatings for orthopedic implants functionalization.

Jiaxin Zhang¹, Haotian Bai¹, Miao Bai²

¹Orthopedic Institute of Jilin Province, Orthopedic Medical Center, The Second Hospital of Jilin University, Changchun 130041, PR China.

Materials Today. Bio

|August 14, 2023

Summary

Bisphosphonate (BP) coatings enhance implant osseointegration and bone repair by delivering BPs locally, avoiding systemic side effects. This review details BP mechanisms, coating methods, and recent advances for clinical translation.

Keywords:

Bisphosphonates Functionalization Implants coating Molecular biological mechanism Osteointegration

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Area of Science:

Biomaterials Science
Orthopedic Surgery
Pharmacology

Background:

Bisphosphonates (BPs) inhibit osteoclastogenesis, crucial for treating osteoporosis and improving bone repair.
Systemic BP administration has limitations; local delivery via implant coatings offers enhanced efficacy and reduced side effects.
A comprehensive review of bisphosphonate coatings for implants is currently lacking.

Purpose of the Study:

To systematically review the cellular and molecular mechanisms of bisphosphonates in regulating bone homeostasis.
To outline and summarize methods for constructing bisphosphonate coatings on implants.
To critically evaluate recent advances in bisphosphonate-coated implants for bone repair and osseointegration.

Main Methods:

Systematic overview of bisphosphonate's cellular and molecular regulatory mechanisms.
Detailed summary of current bisphosphonate coating construction methods (chemical reaction, porous carriers, organic films).
Critical evaluation of preclinical and clinical studies on bisphosphonate-coated implants.

Main Results:

Bisphosphonates modulate osteoclast, osteocyte, osteoblast, and bone mesenchymal stem cell activity.
Various coating techniques demonstrate feasibility for local bisphosphonate delivery.
Emerging data show promise for bisphosphonate-coated implants in enhancing bone repair and osseointegration.

Conclusions:

Bisphosphonate coatings represent a promising strategy for localized bone enhancement, improving implant integration.
Further research and clinical translation are needed to fully realize the potential of bisphosphonate-coated implants.
This review provides a foundation for future development in this field.