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Microdissection of Mouse Brain into Functionally and Anatomically Different Regions
Published on: February 15, 2021
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Dissecting the brain with spatially resolved multi-omics.
Yijia Fangma1, Mengting Liu1, Jie Liao2
1Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province, School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, 310053, China.
Journal of Pharmaceutical Analysis
|August 14, 2023
Summary
Spatially resolved multi-omics technologies offer powerful insights into brain complexity. These advanced techniques map gene expression, proteins, and metabolites, aiding in understanding brain disorders and functions.
Area of Science:
- Neuroscience
- Molecular Biology
- Genomics
Background:
- Brain research increasingly utilizes spatially resolved multi-omics to understand its complex heterogeneity.
- Technologies like spatial transcriptomics, proteomics, and metabolomics are crucial for this exploration.
Purpose of the Study:
- To review major spatial transcriptomics, proteomics, and metabolomics technologies.
- To discuss their applications in neuroscience, including brain atlasing and disease mechanisms.
Main Methods:
- Focus on next-generation sequencing and image-based spatial transcriptomics.
- Highlight mass spectrometry imaging for spatial proteomics and metabolomics.
Main Results:
- Spatial multi-omics aids in building brain atlases and understanding neuron gene expression.
- These technologies help elucidate neuronal communication and CNS disorder mechanisms.
Conclusions:
- Spatial multi-omics provides a comprehensive view of molecular mechanisms in the brain.
- Future work requires integrating these technologies for real-time analysis and whole-brain profiling.
Keywords:
Central nervous system disordersMulti-omicsSpatial metabolomicsSpatial proteomicsSpatial transcriptomicsMore Related Videos
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