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Related Concept Videos

Genomics02:02

Genomics

Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
Proteomics01:33

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term proteomics...
Brain Imaging01:14

Brain Imaging

Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic Stimulation (TMS).

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Related Experiment Video

Updated: Jul 1, 2026

Microdissection of Mouse Brain into Functionally and Anatomically Different Regions
08:06

Microdissection of Mouse Brain into Functionally and Anatomically Different Regions

Published on: February 15, 2021

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Dissecting the brain with spatially resolved multi-omics.

Yijia Fangma1, Mengting Liu1, Jie Liao2

  • 1Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province, School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, 310053, China.

Journal of Pharmaceutical Analysis
|August 14, 2023
PubMed
Summary
This summary is machine-generated.

Spatially resolved multi-omics technologies offer powerful insights into brain complexity. These advanced techniques map gene expression, proteins, and metabolites, aiding in understanding brain disorders and functions.

Keywords:
Central nervous system disordersMulti-omicsSpatial metabolomicsSpatial proteomicsSpatial transcriptomics

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Area of Science:

  • Neuroscience
  • Molecular Biology
  • Genomics

Background:

  • Brain research increasingly utilizes spatially resolved multi-omics to understand its complex heterogeneity.
  • Technologies like spatial transcriptomics, proteomics, and metabolomics are crucial for this exploration.

Purpose of the Study:

  • To review major spatial transcriptomics, proteomics, and metabolomics technologies.
  • To discuss their applications in neuroscience, including brain atlasing and disease mechanisms.

Main Methods:

  • Focus on next-generation sequencing and image-based spatial transcriptomics.
  • Highlight mass spectrometry imaging for spatial proteomics and metabolomics.

Main Results:

  • Spatial multi-omics aids in building brain atlases and understanding neuron gene expression.
  • These technologies help elucidate neuronal communication and CNS disorder mechanisms.

Conclusions:

  • Spatial multi-omics provides a comprehensive view of molecular mechanisms in the brain.
  • Future work requires integrating these technologies for real-time analysis and whole-brain profiling.