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[Atenolol poisoning].

K Hagemann

    Deutsche Medizinische Wochenschrift (1946)
    |October 3, 1986
    PubMed
    Summary
    This summary is machine-generated.

    A patient survived a massive atenolol overdose, reaching the highest recorded blood level. Prompt medical treatment, including supportive care and medications, was crucial for her recovery.

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    Area of Science:

    • Clinical Toxicology
    • Pharmacology
    • Emergency Medicine

    Background:

    • Atenolol is a beta-blocker commonly used to manage hypertension and other cardiovascular conditions.
    • Intentional overdoses of beta-blockers can lead to severe bradycardia, hypotension, and central nervous system depression.
    • Diazepam, a benzodiazepine, is often used for its anxiolytic and sedative properties.

    Observation:

    • A 44-year-old obese female presented with deep coma and hypothermia (28.9°C) 24 hours after ingesting 200 mg of diazepam and 1000 mg of atenolol with suicidal intent.
    • The patient exhibited an extremely high blood atenolol level of 250 mg/l, significantly exceeding the therapeutic range (0.2–0.5 mg/l).

    Findings:

    • Despite the life-threateningly high atenolol concentration, the patient received immediate medical intervention.

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  • Treatment included gastric lavage, activated charcoal, and cardiorespiratory support with orciprenaline, dopamine, and dobutamine.

    • Implications:

    • This case highlights the potential for survival even with record-breaking atenolol levels when aggressive and timely medical management is provided.
    • It underscores the importance of comprehensive supportive care in managing severe beta-blocker poisoning.
    • Further research into the pharmacokinetics and management strategies for extreme beta-blocker overdoses may be warranted.