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Kendall's tau test, also known as the Kendall rank coefficient test, is a nonparametric method for assessing association between two variables. This test is particularly useful for identifying significant correlations when the distributions of the sample and population are unknown. Developed in 1938 by the British statistician Sir Maurice George Kendall, the tau coefficient (denoted as τ) serves as a rank correlation coefficient, with values ranging from -1 to +1.
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Shearing stress, denoted by the Greek letter tau (τ), is stress caused by forces acting transversely on an object. These forces create internal ones within the entity in the plane where the external forces are applied. The resultant of these internal forces is the shear in the section.
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Big Tau: Structure, Evolutionary Divergence, and Emerging Roles in Cytoskeletal Dynamics and Tauopathies.

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Analyses of exon 4a structure reveal unique properties of Big tau.

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In Vitro Aggregation Assays Using Hyperphosphorylated Tau Protein
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Big tau: What, how, where and why.

Itzhak Fischer1

  • 1Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA.

Cytoskeleton (Hoboken, N.J.)
|August 14, 2023
PubMed
Summary

Big tau, a large tau protein isoform, is understudied despite its potential roles in neuronal function and neurodegenerative diseases like tauopathies. Further research is needed to understand its physiological and pathological significance.

Keywords:
cytoskeletonmicrotubulesneuronstauopathies

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Area of Science:

  • Neuroscience
  • Molecular Biology
  • Biochemistry

Background:

  • Tau proteins (45-60 kDa) are crucial for microtubule dynamics and neuronal structure.
  • Tauopathies involve tau pathology, but less is known about the Big tau isoform.
  • Big tau (110 kDa) is a unique, longer tau isoform with limited research.

Purpose of the Study:

  • To review the current knowledge on Big tau structure and expression.
  • To explore Big tau's potential physiological roles, particularly in axonal transport.
  • To consider Big tau's implications in tauopathies and neurodegeneration.

Main Methods:

  • Literature review and synthesis of existing research on Big tau.
  • Analysis of Big tau's structural features and expression patterns.
  • Discussion of Big tau's proposed functions and pathological relevance.

Main Results:

  • Big tau is expressed in peripheral and central nervous systems during specific developmental stages.
  • A potential role for Big tau in enhancing axonal transport is proposed.
  • Big tau may play a role in preventing tau aggregation in tauopathies.

Conclusions:

  • Significant knowledge gaps persist regarding Big tau's physiological functions.
  • Big tau warrants further investigation for its role in neuronal health and disease.
  • Understanding Big tau could offer new therapeutic avenues for tauopathies.