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Updated: Jul 19, 2025

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Published on: June 13, 2022
Enantioselective Total Synthesis of the Cephalotaxus Alkaloid (-)-Cephalotine A
Peng-Zhen Sheng1,2, Lu-Lu Li1, Zhi-Bin Ni1,2
1State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.
Abstract:
Cephalotine A, a recently isolated Cephalotaxus alkaloid, was first synthesized enantioselectively through three critical reactions. SmI2 -mediated radical cyclization of lactone and aldehyde to forge the final ring system, Chang's iridium-catalyzed C-H amidation to construct pyrrolidone stereoselectively, and Carreria's dual Ir/amine catalyzed allylation to install the vicinal tertiary stereocenters.
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