Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Necrosis

Necrosis

Necrosis is considered as an “accidental” or unexpected form of cell death that ends in cell lysis. The first noticeable mention of “necrosis” was in 1859 when Rudolf Virchow used this term to describe advanced tissue breakdown in his compilation titled “Cell Pathology”.
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Concentrically Encapsulated Dual-Enzyme Capsules for Synergistic Metabolic Disorder Redressing and Cytotoxic Intermediates Scavenging.

Nanomaterials (Basel, Switzerland)·2022

Same author

Investigation of Using Sky Openness Ratio as Predictor for Navigation Performance in Urban-like Environment to Support PBN in UTM.

Sensors (Basel, Switzerland)·2022

Same author

Salt crust-assisted thermal decomposition method for direct and simultaneous quantification of polypropylene microplastics and organic contaminants in high organic matter soils.

Analytica chimica acta·2022

Same author

F-box protein 17 promotes glioma progression by regulating glycolysis pathway.

Bioscience, biotechnology, and biochemistry·2022

Same author

AlzCode: a platform for multiview analysis of genes related to Alzheimer's disease.

Bioinformatics (Oxford, England)·2022

Same author

Clinical effect of minimally invasive aspiration and drainage of intracranial hematoma in the treatment of cerebral hemorrhage.

Pakistan journal of medical sciences·2022

Same journal

Tracking Synthetic Adhesins on Bacterial Surfaces with Immunofluorescence Microscopy.

Methods in molecular biology (Clifton, N.J.)·2026

Same journal

Post-Selection Methods for Analyzing mRNA Display Selections and Optimization of Hits.

Methods in molecular biology (Clifton, N.J.)·2026

Same journal

High-Performance Computing in Tandem Mass Spectrometry (MS/MS) Peptide Identification.

Methods in molecular biology (Clifton, N.J.)·2026

Same journal

Engineering and Adapting Disulfide-Containing Proteins to Enable Intracellular Functionality.

Methods in molecular biology (Clifton, N.J.)·2026

Same journal

AI-Driven Protein Research: From Prediction to Design.

Methods in molecular biology (Clifton, N.J.)·2026

Same journal

Methods for the In Vitro Selection of Protein and Peptide Libraries Using mRNA Display.

Methods in molecular biology (Clifton, N.J.)·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jul 19, 2025

Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics

Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics

Published on: March 15, 2024

Membrane Integrity Assay in Ferroptosis.

Chao Deng¹, Yangchun Xie²

¹Department of Oncology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.

Methods in Molecular Biology (Clifton, N.J.)

|August 14, 2023

Summary

This summary is machine-generated.

Ferroptosis, a cell death form driven by iron and oxidative stress, involves lipid peroxidation that damages cell membranes. This study reviews methods to detect this plasma membrane damage during ferroptosis.

Keywords:

Ferroptosis Flow cytometry Oxidoreductase Plasma membrane rupture Transmission electron microscopy

More Related Videos

Ferritinophagy: Assessing the Selective Degradation of Iron by Autophagy in Human Fibroblasts

Ferritinophagy: Assessing the Selective Degradation of Iron by Autophagy in Human Fibroblasts

Published on: February 23, 2024

Cell Membrane Repair Assay Using a Two-photon Laser Microscope

Cell Membrane Repair Assay Using a Two-photon Laser Microscope

Published on: January 2, 2018

Related Experiment Videos

Last Updated: Jul 19, 2025

Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics

Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics

Published on: March 15, 2024

Ferritinophagy: Assessing the Selective Degradation of Iron by Autophagy in Human Fibroblasts

Ferritinophagy: Assessing the Selective Degradation of Iron by Autophagy in Human Fibroblasts

Published on: February 23, 2024

Cell Membrane Repair Assay Using a Two-photon Laser Microscope

Cell Membrane Repair Assay Using a Two-photon Laser Microscope

Published on: January 2, 2018

Area of Science:

Cellular Biology
Biochemistry
Pathology

Background:

Ferroptosis is a regulated cell death pathway.
It is characterized by iron accumulation and lipid peroxidation.
Plasma membrane damage is a key event in ferroptosis.

Purpose of the Study:

To summarize techniques for detecting plasma membrane integrity during ferroptosis.
To elucidate the mechanisms of ferroptotic membrane damage.

Main Methods:

Transmission electron microscopy (TEM) analysis.
Flow cytometry analysis.
Oxidoreductase-mediated membrane damage assessments.

Main Results:

The chapter outlines various methods to assess ferroptosis-induced membrane damage.
These techniques help understand the progression and consequences of ferroptosis.

Conclusions:

Detecting plasma membrane integrity is vital for studying ferroptosis.
Understanding these mechanisms is key to comprehending this cell death pathway.