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Updated: Jul 19, 2025
Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model
Published on: January 12, 2022
Increased Risk of Celiac Disease in Patients with Uveitis
Yosef Milstein1, Elianora Haiimov2, Mordechai Slae2
1Department of Ophthalmology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
Purpose:
To examine whether patients with non-infectious uveitis (NIU) are at increased risk for celiac disease (CeD).
Methods:
Celiac antibody testing was completed in 112 patients. The control group included patients who had undergone upper endoscopy for suspicion of CeD.
Results:
2/112 (1.79%) of patients with NIU had positive anti-tTG serology and CeD was confirmed in both patients. When compared to the expected risk of CeD in the general Israeli population of 0.31%, this corresponded to an odds ratio of 5.77 (95% CI 1.4118 to 23.4737, P = 0.049). Three additional patients had positive serology for CeD but the diagnosis was not confirmed.
Conclusions:
An increased risk of CeD was detected in patients with NIU. We therefore recommend screening for CeD in NIU patients. Larger prospective studies are required to further validate these results.
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