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Related Concept Videos

Hypersensitivities01:30

Hypersensitivities

739
Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
739
Treatment for Pulmonary Arterial Hypertension: Prostacyclin Receptor Agonists01:23

Treatment for Pulmonary Arterial Hypertension: Prostacyclin Receptor Agonists

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Prostacyclin receptor agonists are a class of therapeutic agents integral to managing pulmonary arterial hypertension (PAH). These drugs operate by mimicking the action of prostaglandin I2, or PGI2, a naturally occurring compound in the body.
These agonists bind to the IPR receptor situated on the plasma membrane of the pulmonary artery smooth muscle cells. This binding triggers a cascade of reactions known as the GS-AC-cAMP-PKA pathway. This pathway results in the relaxation of smooth muscle...
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Adrenal Gland Disorders01:27

Adrenal Gland Disorders

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Adrenal gland disorders manifest when the production of adrenal hormones deviates from the norm, resulting in either excessive or insufficient concentrations.
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
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Allergic Drug Reactions01:27

Allergic Drug Reactions

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Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
876
Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors01:20

Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors

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Antiplatelet drugs emerge as frontline defenders against the insidious threat of thromboembolic diseases, where abnormal clots obstruct vital blood vessels. These drugs stand as bulwarks, inhibiting platelet aggregation and clot formation, thereby mitigating the risk of life-threatening conditions like myocardial infarction, coronary artery disease, and thrombotic strokes.
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...
563
Hypoglycemia and Glucagon01:15

Hypoglycemia and Glucagon

297
Without prolonged fasting, healthy individuals maintain blood glucose levels above 3.5 mM due to a well-adapted neuroendocrine counterregulatory system that effectively prevents acute hypoglycemia, a potentially life-threatening condition. The primary clinical scenarios for hypoglycemia encompass diabetes treatment, inappropriate production of endogenous insulin or insulin-like substances by tumors, and the use of glucose-lowering agents in non-diabetic individuals. Notably, hypoglycemia in the...
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Updated: Jul 19, 2025

Basophil Activation Test for Investigation of IgE-Mediated Mechanisms in Drug Hypersensitivity
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Basophil Activation Test for Investigation of IgE-Mediated Mechanisms in Drug Hypersensitivity

Published on: September 16, 2011

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Progestogen Hypersensitivity.

Sergio E Chiarella1, Kathleen M Buchheit2, Dinah Foer2

  • 1Division of Allergic Diseases, Mayo Clinic, Rochester, Minn.

The Journal of Allergy and Clinical Immunology. in Practice
|August 14, 2023
PubMed
Summary
This summary is machine-generated.

Progestogen hypersensitivity (PH) causes allergic reactions to progesterone. Diagnosis relies on symptom timing, and challenges may be needed, with tailored treatments like desensitization offering relief.

Keywords:
Autoimmune progesterone dermatitisEndocrine allergyInfertilityMenstrual cycleProgesteroneProgestinSteroid hormone allergy

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Area of Science:

  • Allergy and Immunology
  • Endocrinology

Background:

  • Progestogen hypersensitivity (PH) presents with varied symptoms including skin reactions, bronchospasm, and anaphylaxis.
  • It can be triggered by endogenous ovarian progesterone or exogenous progestins.

Purpose of the Study:

  • To review the diagnostic challenges and treatment strategies for progestogen hypersensitivity.
  • To highlight the importance of symptom timing in diagnosing PH.

Main Methods:

  • Review of clinical presentations, diagnostic approaches, and therapeutic options for PH.
  • Discussion of progesterone skin testing limitations and the role of progestogen challenges.

Main Results:

  • Accurate PH diagnosis depends critically on the timing of symptom onset relative to the menstrual cycle or progestin exposure.
  • Current diagnostic tests like skin testing have suboptimal sensitivity and specificity.
  • Progestogen challenge is a key diagnostic tool for suspected exogenous PH.

Conclusions:

  • Tailored treatment strategies are essential for PH management.
  • Treatment options include symptom management, ovulation suppression, and progesterone desensitization.
  • Further research is needed to elucidate PH mechanisms, validate diagnostic criteria, and standardize treatments.