Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Urinary Tract Calculi IV: Nutrition Therapy and Prevention01:27

Urinary Tract Calculi IV: Nutrition Therapy and Prevention

11
Management of renal calculi focuses on effective strategies like tailored nutrition and hydration therapy. Adjusting diet and fluid intake reduces stone formation and recurrence, making these interventions simple yet powerful in kidney stone prevention and management.Understanding Kidney StonesKidney stones form when calcium, oxalate, uric acid, and cystine concentrate and crystallize in urine. Factors contributing to their formation include genetic predisposition, certain medical conditions,...
11
Hypothesis Test for Test of Independence01:16

Hypothesis Test for Test of Independence

3.6K
The test of independence is a chi-square-based test used to determine whether two variables or factors are independent or dependent. This hypothesis test is used to examine the independence of the variables. One can construct two qualitative survey questions or experiments based on the variables in a contingency table. The goal is to see if the two variables are unrelated (independent) or related (dependent). The null and alternative hypotheses for this test are:
H0: The two variables (factors)...
3.6K
Urinary Tract Calculi I: Introduction01:28

Urinary Tract Calculi I: Introduction

16
Renal calculi, or kidney stones, are solid deposits of minerals and salts formed inside the kidneys. In medical terminology, "calculus" refers to the stone itself, while "lithiasis" describes the process of stone formation. Depending on their location within the urinary system, these stones may be classified as either urolithiasis, when situated within the urinary tract, or nephrolithiasis, when located within the kidneys. Each term signifies the specific impact of the stone.Predisposition...
16
Urinary Tract Calculi III: Medical Management01:30

Urinary Tract Calculi III: Medical Management

9
The diagnosis of renal calculi involves several imaging techniques, including non-contrast CT scans and ultrasound. These methods help visualize kidney stones, assess their size and location, and detect possible obstructions. Additionally, Measuring urine pH is useful for diagnosing specific stone types, such as struvite (alkaline pH) and uric acid stones (acidic pH). Cystine stones are primarily linked to cystinuria, a genetic condition. A urinalysis helps detect blood in the urine (hematuria)...
9
Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations01:26

Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations

13
Renal calculi, commonly termed kidney stones, are crystalline solid masses that form in the kidneys but can occur at any point within the urinary system, encompassing the kidneys, ureters, bladder, and urethra.The pathophysiology of renal stones involves several key factors: supersaturation of the urine with stone-forming constituents, changes in urine pH, a decrease in urine volume, and the presence of substances that promote or inhibit stone formation.Supersaturation of Urine: This is the...
13
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

13.6K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
13.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Conversion of Gaseous Hg<sup>0</sup> Capture by CuS from Surface Adsorption to the Replacement Reaction through Intermittent Acid Washing.

Environmental science & technology·2026
Same author

A critical role for mitochondrial dynamics in cigarette smoke condensate-induced RPE senescence.

Free radical biology & medicine·2026
Same author

Non-enzymatic preparation of porous arrowroot starch: pore forming mechanism, physicochemical properties, and adsorption performance for food and environmental applications.

Food chemistry·2026
Same author

Erratum: [Corrigendum] Proliferation, migration and invasion of triple negative breast cancer cells are suppressed by berbamine via the PI3K/Akt/MDM2/p53 and PI3K/Akt/mTOR signaling pathways.

Oncology letters·2026
Same author

Self-Assembly Ordered Layered Gels for Thermochromic Smart Windows With Excellent Electromagnetic Shielding Properties.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

A Moderate-Affinity Antibody-Drug Conjugate Targeting B7-H3 Exerts Potent Antitumor Efficacy.

Pharmaceuticals (Basel, Switzerland)·2026

Related Experiment Video

Updated: Jul 19, 2025

Modeling Alcohol Consumption in Rodents Using Two-Bottle Choice Home Cage Drinking and Microstructural Analysis
08:45

Modeling Alcohol Consumption in Rodents Using Two-Bottle Choice Home Cage Drinking and Microstructural Analysis

Published on: November 8, 2024

647

Association between alcohol and urolithiasis: a mendelian randomization study.

Shijian Yang1, Wenyue Tan2, Baian Wei2

  • 1Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China.

Urolithiasis
|August 15, 2023
PubMed
Summary

Mendelian randomization analysis suggests alcohol intake frequency, but not overall alcohol consumption, may causally increase urolithiasis risk. Further research is needed to confirm this association between alcohol and kidney stones.

Keywords:
AlcoholCausalityFinnGen databaseMendelian randomizationUrolithiasis

More Related Videos

Estimation of Urinary Nanocrystals in Humans using Calcium Fluorophore Labeling and Nanoparticle Tracking Analysis
07:45

Estimation of Urinary Nanocrystals in Humans using Calcium Fluorophore Labeling and Nanoparticle Tracking Analysis

Published on: February 9, 2021

3.6K
Vinyl Chloride and High-Fat Diet as a Model of Environment and Obesity Interaction
09:15

Vinyl Chloride and High-Fat Diet as a Model of Environment and Obesity Interaction

Published on: January 12, 2020

6.4K

Related Experiment Videos

Last Updated: Jul 19, 2025

Modeling Alcohol Consumption in Rodents Using Two-Bottle Choice Home Cage Drinking and Microstructural Analysis
08:45

Modeling Alcohol Consumption in Rodents Using Two-Bottle Choice Home Cage Drinking and Microstructural Analysis

Published on: November 8, 2024

647
Estimation of Urinary Nanocrystals in Humans using Calcium Fluorophore Labeling and Nanoparticle Tracking Analysis
07:45

Estimation of Urinary Nanocrystals in Humans using Calcium Fluorophore Labeling and Nanoparticle Tracking Analysis

Published on: February 9, 2021

3.6K
Vinyl Chloride and High-Fat Diet as a Model of Environment and Obesity Interaction
09:15

Vinyl Chloride and High-Fat Diet as a Model of Environment and Obesity Interaction

Published on: January 12, 2020

6.4K

Area of Science:

  • Genetics
  • Epidemiology
  • Urology

Background:

  • The relationship between alcohol consumption and urolithiasis (kidney stones) is not fully understood.
  • Previous observational studies suggest an association, but causality remains uncertain.

Purpose of the Study:

  • To investigate the potential causal link between alcohol intake and the risk of developing urolithiasis.
  • To differentiate the effects of alcohol intake frequency from overall alcohol consumption on kidney stone risk.

Main Methods:

  • A two-sample Mendelian randomization (MR) analysis was employed.
  • Genetic instruments, including 73 single-nucleotide polymorphisms (SNPs) for alcohol intake frequency (AIF) and 69 SNPs for alcohol consumption (AC), were utilized.
  • Standard MR methods such as inverse-variance weighted (IVW), weighted median, and MR-Egger regression were applied.

Main Results:

  • MR analysis indicated a borderline significant association between higher alcohol intake frequency (AIF) and an increased risk of urolithiasis (IVW: OR=1.29, p=0.036).
  • The weighted median method also supported this association (OR=1.44, p=0.008).
  • No significant causal effect of overall alcohol consumption (AC) on urolithiasis risk was detected (IVW: OR=0.74, p=0.173).

Conclusions:

  • The study suggests a potential causal relationship between the frequency of alcohol intake and the risk of urolithiasis.
  • Alcohol consumption patterns, specifically frequency, may play a role in kidney stone formation, warranting further investigation.