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Benzodiazepines Reduce Blood Pressure in Short Term: A Systematic Review and Meta-analysis
Bhupinder Solanki1,2, Ridhi Goel1, Lalit K Gupta3
1Department of Pharmacology, Lady Hardinge Medical College & Smt. S.K. Hospital, New Delhi, 110001, India.
Benzodiazepines may help lower blood pressure in hypertensive patients, showing effects comparable to standard drugs. Further research is needed to confirm long-term benefits and optimal use as an add-on therapy.
Area of Science:
- Pharmacology
- Cardiovascular Medicine
- Clinical Trials
Background:
- Benzodiazepines are prescribed for anxiety and insomnia due to their anxiolytic properties.
- They may possess hypotensive effects through central nervous system potentiation of GABA and vasodilatory actions.
- Previous studies on benzodiazepines' blood pressure-lowering effects in hypertension are conflicting.
Conclusions:
- Benzodiazepines may serve as a short-term add-on antihypertensive therapy for a subset of patients.
- Existing data are encouraging, but further clinical trials and mechanistic research are necessary to validate long-term benefits.
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