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Cutaneous immune-related adverse events from immune checkpoint inhibitor therapy: Moving beyond "maculopapular rash"

Blair S Allais1, Christopher J Fay2, Daniel Y Kim3

  • 1Inova Schar Cancer Institute, Melanoma and Skin Cancer Center, Fairfax, Virginia, USA.

Immunological Reviews
|August 16, 2023
PubMed

Insights

Understanding the causes of toxicity from immune checkpoint inhibitor therapy is key. Cutaneous immune-related adverse events are linked to better survival, requiring careful treatment balance.

Area of Science:

  • Oncology
  • Dermatology
  • Immunology

Background:

  • Immune checkpoint inhibitor (ICI) therapy has revolutionized cancer treatment.
  • Cutaneous immune-related adverse events (ciAEs) are common side effects of ICI therapy.
  • Distinguishing toxicity from therapeutic effects is crucial for patient management.

Purpose of the Study:

  • To explore the drivers of toxicity, tumor response, and resistance in patients receiving ICI therapy.
  • To enhance diagnostic specificity for ciAEs through consensus definitions.
  • To emphasize the importance of multidisciplinary care in managing ciAEs.

Main Methods:

  • Analysis of large, well-powered population-level studies.
  • Examination of institutional cohort data.
  • Integration of cellular-level data.

Main Results:

  • Cutaneous immune-related adverse events are associated with improved patient survival.
  • Consensus disease definitions can increase diagnostic specificity for ciAEs.
  • Balancing immunosuppression, anti-tumor effects, and quality of life is essential for treatment.

Conclusions:

  • Dermatologists play a vital role in advancing research on ciAEs.
  • Multidisciplinary care is critical for optimizing clinical and translational research outcomes in cancer patients with adverse events.
  • Further research is needed to fully understand and manage ciAEs effectively.
Keywords:
cutaneous immune-related adverse eventsimmune checkpoint inhibitoroncodermatology

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