Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Gastritis III: Clinical Manifestations and Management

Gastritis III: Clinical Manifestations and Management

The clinical manifestations of gastritis can vary depending on the cause and type of gastritis, but some common symptoms may include the following.
Clinical manifestations of acute gastritis
The patient with acute gastritis may have a rapid onset of symptoms, such as epigastric pain or discomfort, dyspepsia, anorexia, hiccups, or nausea and vomiting, which can last from a few hours to a few days. Erosive or hemorrhagic gastritis may cause bleeding, which may manifest as blood in vomit or as...

Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists

Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists

Neurokinin 1 (NK1) receptors are distributed across the GI tract, vagal afferents, and key CNS regions including the central vomiting center and chemoreceptor trigger zone (CTZ) Chemotherapy agents stimulate enterochromaffin cells in the gastrointestinal (GI) tract to release large amounts of substance P (SP). SP is a neuropeptide released by specific sensory nerves in response to many different stressors, including those in the GI mucosa affected by chemotherapy. SP binds and activates...

Gastritis-II: Pathophysiology

Gastritis-II: Pathophysiology

Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Gut Microbiota as a Biomarker and Target in Biologic Therapy for Autoimmune and Immune-Mediated Arthritis: A Systematic Review.

The Journal of rheumatology·2026

Same author

Long-Term Cardiac Sequelae in Lyme Carditis: A Review.

Current cardiology reviews·2026

Same author

Nicotine pouches and youth: emerging patterns and potential cardiovascular risks.

Frontiers in public health·2025

Same author

Efficacy and Safety of Low Volume Bowel Preparation for Colonoscopy in Hospitalized Patients: A Randomized Noninferiority Trial.

Journal of clinical gastroenterology·2025

Same author

Risk of Nephrolithiasis in Cirrhosis: A Comparison between MASLD Cirrhosis and Cirrhosis Due to Other Etiologies.

Southern medical journal·2025

Same author

Complete Myocardial Bridging.

JACC. Case reports·2025

Same journal

Believe Your Patient Who Denies Alcohol Dependence/Celiac Disease as a Cause of Wernicke Encephalopathy.

ACG case reports journal·2026

Same journal

Splenic Artery Hemorrhage as a Rare Delayed Complication of Percutaneous Endoscopic Gastrostomy.

ACG case reports journal·2026

Same journal

Porto Sinusoidal Vascular Disorder Manifesting as Diffuse Arterio-Portal Fistulae and Portal Hypertension After Donation-After-Circulatory-Death Liver Transplantation.

ACG case reports journal·2026

Same journal

Fenbendazole-Associated Drug-Induced Liver Injury with Concomitant Use of Tauroursodeoxycholic Acid.

ACG case reports journal·2026

Same journal

Infiltrating Presacral Neuroendocrine Tumor: An Atypical Cause of Lower Gastrointestinal Bleeding.

ACG case reports journal·2026

Same journal

A Case Report and Literature Review of a Rectal Gastrointestinal Stromal Tumor.

ACG case reports journal·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jul 19, 2025

An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis

An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis

Published on: September 12, 2019

Immune Checkpoint Inhibitor-Induced Hemorrhagic Gastritis.

Karthik Mathialagan¹, Cheng-Hung Tai², Samdish Sethi¹

¹Department of Medicine, Yale-New Haven Health-Bridgeport Hospital, Bridgeport, CT.

ACG Case Reports Journal

|August 16, 2023

Summary

This summary is machine-generated.

Immune checkpoint inhibitors (ICIs) treat cancer by enhancing immune response but can cause immune-related adverse events. This case highlights hemorrhagic gastritis as a rare complication of anti-programmed cell death-1 therapy.

Area of Science:

Oncology
Immunology

Background:

Immune checkpoint inhibitors (ICIs) target cytotoxic T-lymphocyte-associated antigen-4, programmed cell death-1, and programmed cell death ligand 1 to restore anti-tumor immunity.

Keywords:

hemorrhagic gastritis immune checkpoint inhibitor immune related adverse events pembrolizumab

More Related Videos

Important Endpoints and Proliferative Markers to Assess Small Intestinal Injury and Adaptation using a Mouse Model of Chemotherapy-Induced Mucositis

Important Endpoints and Proliferative Markers to Assess Small Intestinal Injury and Adaptation using a Mouse Model of Chemotherapy-Induced Mucositis

Published on: May 12, 2019

Monitoring PD-1-Blocking Antibodies Bound to T Cells Derived from a Drop of Peripheral Blood

Monitoring PD-1-Blocking Antibodies Bound to T Cells Derived from a Drop of Peripheral Blood

Published on: February 5, 2020

Related Experiment Videos

Last Updated: Jul 19, 2025

An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis

An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis

Published on: September 12, 2019

Important Endpoints and Proliferative Markers to Assess Small Intestinal Injury and Adaptation using a Mouse Model of Chemotherapy-Induced Mucositis

Important Endpoints and Proliferative Markers to Assess Small Intestinal Injury and Adaptation using a Mouse Model of Chemotherapy-Induced Mucositis

Published on: May 12, 2019

Monitoring PD-1-Blocking Antibodies Bound to T Cells Derived from a Drop of Peripheral Blood

Monitoring PD-1-Blocking Antibodies Bound to T Cells Derived from a Drop of Peripheral Blood

Published on: February 5, 2020

ICIs can disrupt peripheral immune tolerance, leading to immune-related adverse events (irAEs).

While common irAEs are well-documented, rare gastrointestinal manifestations are increasingly reported.